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Artículo

Anti-tumor effect of SLPI on mammary but not colon tumor growth

Amiano, Nicolás OscarIcon ; Costa, Maria JulietaIcon ; Reiteri, Macarena R.; Payés, CristianIcon ; Guerrieri, DiegoIcon ; Tateosian, Nancy LilianaIcon ; Sanchez, Mercedes LeonorIcon ; Maffia, Paulo CesarIcon ; Diament, Miriam; Karas, Romina AlejandraIcon ; Orqueda, Andres JavierIcon ; Rizzo, Miguel; Alaniz, Laura DanielaIcon ; Mazzolini, Guillermo; Klein, Slobodanka; Sallenave, Jean-Michel; Chuluyan, Hector EduardoIcon
Fecha de publicación: 02/2013
Editorial: Wiley
Revista: Journal of Cellular Physiology
ISSN: 0021-9541
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor that was related to cancer development and metastasis dissemination on several types of tumors. However, it is not known the effect of SLPI on mammary and colon tumors. The aim of this study was to examine the effect of SLPI on mammary and colon tumor growth. The effect of SLPI was tested on in vitro cell apoptosis and in vivo tumor growth experiments. SLPI over-expressing human and murine mammary and colon tumor cells were generated by gene transfection. The administration of murine mammary tumor cells over-expressing high levels of SLPI did not develop tumors in mice. On the contrary, the administration of murine colon tumor cells over-expressing SLPI, developed faster tumors than control cells. Intratumoral, but not intraperitoneal administration of SLPI, delayed the growth of tumors and increased the survival of mammary but not colon tumor bearing mice. In vitro culture of mammary tumor cell lines treated with SLPI, and SLPI producer clones were more prone to apoptosis than control cells, mainly under serum deprivation culture conditions. Herein we demonstrated that SLPI induces the apoptosis of mammary tumor cells in vitro and decreases the mammary but not colon tumor growth in vivo. Therefore, SLPI may be a new potential therapeutic tool for certain tumors, such as mammary tumors.
Palabras clave: Cancer , Slpi , Apoptosis , Mammary Tumor , Colon Tumor
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/14055
URL: http://onlinelibrary.wiley.com/doi/10.1002/jcp.24153/abstract
DOI: http://dx.doi.org/10.1002/jcp.24153
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos(IFIBYNE)
Articulos de INST.DE FISIOL., BIOL.MOLECULAR Y NEUROCIENCIAS
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Amiano, Nicolás Oscar; Costa, Maria Julieta; Reiteri, Macarena R.; Payés, Cristian; Guerrieri, Diego; et al.; Anti-tumor effect of SLPI on mammary but not colon tumor growth; Wiley; Journal of Cellular Physiology; 228; 2; 2-2013; 469-475
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