Artículo
Polarization of MTIP is a signature of gliding locomotion in Plasmodium ookinetes and sporozoites
Siden Kiamos, Inga; Goosmann, Christian; Buscaglia, Carlos Andres
; Brinkmann, Volker; Matuschewski, Kai; Montagna, Georgina Nuri
Fecha de publicación:
01/2020
Editorial:
Elsevier Science
Revista:
Molecular and Biochemical Parasitology
ISSN:
0166-6851
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Gliding motility and cell invasion are essential for the successful transmission of Plasmodium parasites. These processes rely on an acto-myosin motor located underneath the parasite plasma membrane. The Myosin A-tail interacting protein (MTIP) connects the class XIV myosin A (MyoA) to the gliding-associated proteins and is essential for assembly of the motor at the inner membrane complex. Here, we assessed the subcellular localization of MTIP in Plasmodium berghei motile stages from wild-type parasites and mutants that lack MyoA or the small heat shock protein 20 (HSP20). We demonstrate that MTIP is recruited to the apical end of motile ookinetes independently of the presence of MyoA. We also show that infective sporozoites displayed a polarized MTIP distribution during gliding, and that this distribution was abrogated in mutant parasites with an aberrant locomotion.
Palabras clave:
CELL POLARITY
,
HSP20
,
MOTILITY
,
MTIP
,
PLASMODIUM
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos (IIBIO)
Articulos de INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOTECNOLOGICAS
Citación
Siden Kiamos, Inga; Goosmann, Christian; Buscaglia, Carlos Andres; Brinkmann, Volker; Matuschewski, Kai; et al.; Polarization of MTIP is a signature of gliding locomotion in Plasmodium ookinetes and sporozoites; Elsevier Science; Molecular and Biochemical Parasitology; 235; 1-2020; 1-4
Compartir
Altmétricas