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dc.contributor.author
Bellia, Fabio  
dc.contributor.author
Suarez, Andrea  
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D'Addario, Claudio  
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Pautassi, Ricardo Marcos  
dc.contributor.author
Fabio, Maria Carolina  
dc.date.available
2021-09-13T19:31:14Z  
dc.date.issued
2021-01  
dc.identifier.citation
Bellia, Fabio; Suarez, Andrea; D'Addario, Claudio; Pautassi, Ricardo Marcos; Fabio, Maria Carolina; Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice; Springer; Psychopharmacology; 238; 1; 1-2021; 215-225  
dc.identifier.issn
0033-3158  
dc.identifier.uri
http://hdl.handle.net/11336/140271  
dc.description.abstract
Serotonin (5-HT) plays an important role in the organization of the central nervous system and in the development of social interaction deficits and psychiatric disorders, including anxiety, depression, and addiction disorders. Notably, disruption of the 5-HT system during sensitive periods of development exerts long-term consequences, including altered anxiety response and problematic use of alcohol. Objective: we analyzed, in mice, the effects of transient 5-HT depletion at infancy or adolescence on subsequent anxiety-like behavior and alcohol intake during adolescence. Methods: C57/BL6 male and female mice were administered a 5-HT synthesis inhibitor (PCPA; 4-chloro-DL-phenylalanine methyl ester hydrochloride) at infancy (postnatal days 14–16 [PD14–16]) or adolescence (PD40–42). Eleven (± 1) days after treatment, mice were assessed for ethanol intake in daily two-bottle choice tests and for anxiety response via the elevated plus maze. Results: Female, but not male, mice transiently depleted of 5-HT at adolescence (but not those depleted at the perinatal stage) exhibited a significant reduction in anxiety response, which was accompanied by a significant reduction on alcohol intake. Conclusion: Transient 5-HT inhibition at adolescence may act, in females, as a protective factor for the emergence of anxiety disorders and problematic use of alcohol during adolescence.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
5-HT  
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ADOLESCENCE  
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ALCOHOL  
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ANXIETY BEHAVIOR  
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EPM  
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INFANCY  
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PCPA  
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SENSITIVE PERIODS  
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Neurociencias  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Transient serotonin depletion at adolescence, but not at early infancy, reduced subsequent anxiety-like behavior and alcohol intake in female mice  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-08-25T19:28:00Z  
dc.identifier.eissn
1432-2072  
dc.journal.volume
238  
dc.journal.number
1  
dc.journal.pagination
215-225  
dc.journal.pais
Alemania  
dc.journal.ciudad
Berlin  
dc.description.fil
Fil: Bellia, Fabio. Università Degli Studi Di Teramo; Italia  
dc.description.fil
Fil: Suarez, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina  
dc.description.fil
Fil: D'Addario, Claudio. Università Degli Studi Di Teramo; Italia. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia  
dc.description.fil
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba; Argentina  
dc.description.fil
Fil: Fabio, Maria Carolina. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina  
dc.journal.title
Psychopharmacology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/10.1007/s00213-020-05670-1  
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info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1007/s00213-020-05670-1