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dc.contributor.author
Bartel, Dianna L.
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Rela, Lorena
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Hsieh, Lawrence
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Greer, Charles A.
dc.date.available
2017-03-17T18:00:40Z
dc.date.issued
2015-06
dc.identifier.citation
Bartel, Dianna L.; Rela, Lorena; Hsieh, Lawrence; Greer, Charles A. ; Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer; Wiley; Journal Of Comparative Neurology; 523; 8; 6-2015; 1145-1161
dc.identifier.issn
0021-9967
dc.identifier.uri
http://hdl.handle.net/11336/14019
dc.description.abstract
Odor information relayed by olfactory bulb projection neurons, mitral and tufted cells (M/T), is modulated by pairs of reciprocal dendrodendritic synaptic circuits in the external plexiform layer (EPL). Interneurons, which are accounted for largely by granule cells, receive depolarizing input from M/T dendrites and in turn inhibit current spread in M/T dendrites via hyperpolarizing reciprocal dendrodendritic synapses. Because the location of dendrodendritic synapses may significantly affect the cascade of odor information, we assessed synaptic properties and density within sublaminae of the EPL and along the length of M/T secondary dendrites. In electron micrographs the M/T to granule cell synapse appeared to predominate and was equivalent in both the outer and inner EPL. However, the dendrodendritic synapses from granule cell spines onto M/T dendrites were more prevalent in the outer EPL. In contrast, individual gephyrin-immunoreactive (IR) puncta, a postsynaptic scaffolding protein at inhibitory synapses used here as a proxy for the granule to M/T dendritic synapse was equally distributed throughout the EPL. Of significance to the organization of intrabulbar circuits, gephyrin-IR synapses are not uniformly distributed along M/T secondary dendrites. Synaptic density, expressed as a function of surface area, increases distal to the cell body. Furthermore, the distributions of gephyrin-IR puncta are heterogeneous and appear as clusters along the length of the M/T dendrites. Consistent with computational models, our data suggest that temporal coding in M/T cells is achieved by precisely located inhibitory input and that distance from the soma is compensated for by an increase in synaptic density.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Olfactory Bulb
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Dendrodendritic Synapses
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External Plexiform Layer
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Gephyrin
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-17T14:29:44Z
dc.journal.volume
523
dc.journal.number
8
dc.journal.pagination
1145-1161
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Bartel, Dianna L.. University Of Yale. School Of Medicine; Estados Unidos
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Fil: Rela, Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
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Fil: Hsieh, Lawrence. University Of Yale. School Of Medicine; Estados Unidos
dc.description.fil
Fil: Greer, Charles A. . University Of Yale. School Of Medicine; Estados Unidos
dc.journal.title
Journal Of Comparative Neurology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/cne.23714/abstract
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/cne.23714
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390432/
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