Artículo
Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment, and breast cancer survival
Singhal, Sandeep K.; Byun, Jung S.; Park, Samson; Yan, Tingfen; Yancey, Ryan; Caban, Ambar; Hernandez, Sara Gil; Hewitt, Stephen M.; Boisvert, Heike; Hennek, Stephanie; Bobrow, Mark; Ahmed, Md Shakir Uddin; White, Jason; Yates, Clayton; Aukerman, Andrew; Vanguri, Rami; Bareja, Rohan; Lenci, Romina; Farré, Paula Lucía
; de Siervi, Adriana
; Nápoles, Anna María; Vohra, Nasreen; Gardner, Kevin
Fecha de publicación:
12/2021
Editorial:
Nature Research
Revista:
Communications Biology
ISSN:
2399-3642
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The use of digital pathology for the histomorphologic profiling of pathological specimens is expanding the precision and specificity of quantitative tissue analysis at an unprecedented scale; thus, enabling the discovery of new and functionally relevant histological features of both predictive and prognostic significance. In this study, we apply quantitative automated image processing and computational methods to profile the subcellular distribution of the multi-functional transcriptional regulator, Kaiso (ZBTB33), in the tumors of a large racially diverse breast cancer cohort from a designated health disparities region in the United States. Multiplex multivariate analysis of the association of Kaiso’s subcellular distribution with other breast cancer biomarkers reveals novel functional and predictive linkages between Kaiso and the autophagy-related proteins, LC3A/B, that are associated with features of the tumor immune microenvironment, survival, and race. These findings identify effective modalities of Kaiso biomarker assessment and uncover unanticipated insights into Kaiso’s role in breast cancer progression.
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Singhal, Sandeep K.; Byun, Jung S.; Park, Samson; Yan, Tingfen; Yancey, Ryan; et al.; Kaiso (ZBTB33) subcellular partitioning functionally links LC3A/B, the tumor microenvironment, and breast cancer survival; Nature Research; Communications Biology; 4; 1; 12-2021; 1-13
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