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Artículo

Sigma-1 antagonism inhibits binge ethanol drinking at adolescence

Ruiz Leyva, Leandro; Salguero, Juan AgustínIcon ; Morón, Ignacio; Portillo-Salido, Enrique; Cendán, Cruz Miguel; Pautassi, Ricardo MarcosIcon
Fecha de publicación: 10/2020
Editorial: Elsevier Ireland
Revista: Drug And Alcohol Dependence
ISSN: 0376-8716
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Drogadicción

Resumen

Ethanol use during adolescence is a significant health problem, yet the pharmacological treatments to reduce adolescent binge drinking are scarce. The present study assessed, in male and female adolescent Wistar rats, if the sigma-1 receptor (S1-R) antagonists S1RA or BD-1063 disrupted ethanol drinking. Methods: Three times a week, for two weeks, the rats received the S1-R antagonists. Thirty min later they were exposed, for 2 h, to a bottle of 8% or 10 % v/v ethanol. A 24 h, two-bottle, ethanol intake test was conducted after termination of these procedures. A subset of these rats was tested for recognition memory via the novel object recognition test. Results: The rats given 64 mg/kg S1RA drank, in each binge session, significantly less than vehicle counterparts. Male rats given 4 or 16 mg/kg S1RA drank significantly less than those given 0 mg/kg in session 3 or in session 1 and 2, respectively; whereas female rats given 4 or 16 mg/kg drank significantly less than females given 0 mg/kg in session 2–5 or in sessions 2–6, respectively. Administration of 32 mg/kg, but not of 2 or 8 mg/kg, BD-1063 suppressed, across sessions, ethanol drinking. S1-R antagonism reduced absolute ethanol drinking at the two-bottle choice post-test. Recognition memory was not affected by the ethanol exposure. Conclusions: The results indicate that S1-R antagonists may be promising targets to prevent increases in ethanol intake at adolescence. The persistent effect of S1-R antagonism in free-choice drinking suggests that modulation of the S1-R is altering plastic effects associated with ethanol exposure.
Palabras clave: ADOLESCENCE , BINGE DRINKING , ETHANOL , RAT , SEX DIFFERENCES , SIGMA-1 RECEPTOR
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/140066
URL: https://linkinghub.elsevier.com/retrieve/pii/S0376871620303793
DOI: http://dx.doi.org/10.1016/j.drugalcdep.2020.108214
Colecciones
Articulos(INIMEC - CONICET)
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Citación
Ruiz Leyva, Leandro; Salguero, Juan Agustín; Morón, Ignacio; Portillo-Salido, Enrique; Cendán, Cruz Miguel; et al.; Sigma-1 antagonism inhibits binge ethanol drinking at adolescence; Elsevier Ireland; Drug And Alcohol Dependence; 215; 10-2020; 1-6
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