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dc.contributor.author
Soler Arias, Elber Alberto
dc.contributor.author
Trigo, Roberto Héctor
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dc.contributor.author
Miceli, Diego Daniel
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dc.contributor.author
Vidal, Patricia Noemi
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dc.contributor.author
Hernandez Blanco, M. F.
dc.contributor.author
Castillo, Victor Alejandro
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dc.date.available
2021-09-09T18:43:36Z
dc.date.issued
2021-01
dc.identifier.citation
Soler Arias, Elber Alberto; Trigo, Roberto Héctor; Miceli, Diego Daniel; Vidal, Patricia Noemi; Hernandez Blanco, M. F.; et al.; Urinary vanillylmandelic acid:creatinine ratio in dogs with pheochromocytoma; Elsevier Science Inc.; Domestic Animal Endocrinology; 74; 106559; 1-2021; 1-7
dc.identifier.issn
0739-7240
dc.identifier.uri
http://hdl.handle.net/11336/140036
dc.description.abstract
Pheochromocytoma diagnosis in dogs is challenging because biochemical tests are not always available. In humans, urinary vanillylmandelic acid (VMA) is part of a pheochromocytoma biochemical diagnostic profile, whereas its diagnostic accuracy is currently unknown in dogs with pheochromocytoma. Prospectively, VMA was determined by HPLC and expressed as the ratio with respect to urinary creatinine (VMA:C). The diagnostic accuracy of the VMA:C ratio was evaluated by analyzing the receiver operating characteristic (ROC) curve in 10 healthy dogs, 8 dogs with pituitary-dependent hypercortisolism, 8 dogs with adrenal-dependent hypercortisolism, and 7 dogs with pheochromocytoma. The pheochromocytoma diagnosis was confirmed by histology and immunohistochemistry in all tumors. The VMA:C ratio was significantly higher in dogs with pheochromocytoma (158 [53.4 to 230.8] × 10−3) than in dogs with adrenal-dependent hypercortisolism (48.1 [24.3 to 144.9] × 10−3; P < 0.05), dogs with pituitary-dependent hypercortisolism (37.5 [32 to 47.1] × 10−3; P < 0.001), and healthy dogs (33.8 [13.3 to 87.9] × 10−3; P < 0.001). When using a VMA:C ratio >58.2 × 10−3 for pheochromocytoma diagnosis, a sensitivity of 85.7% and a specificity of 88.4% were obtained. Nevertheless, when using a cut-off ratio of 4 times the median VMA:C ratio determined in healthy dogs, there was no overlap (100% specificity). The area under the ROC curve indicated that the VMA:C ratio test could be used to discriminate between dogs with and without pheochromocytoma, what leads to the conclusion that it is useful for pheochromocytoma diagnosis in dogs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc.
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADRENAL TUMOR
dc.subject
HYPERCORTISOLISM
dc.subject
NEUROENDOCRINE TUMOR
dc.subject
PARAGANGLIOMA
dc.subject
PHEOCHROMOCYTOMA
dc.subject
VANILLYLMANDELIC ACID
dc.subject.classification
Otras Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
Urinary vanillylmandelic acid:creatinine ratio in dogs with pheochromocytoma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-07-30T19:15:12Z
dc.journal.volume
74
dc.journal.number
106559
dc.journal.pagination
1-7
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Soler Arias, Elber Alberto. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Trigo, Roberto Héctor. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Miceli, Diego Daniel. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Vidal, Patricia Noemi. Universidad de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Hernandez Blanco, M. F.. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Castillo, Victor Alejandro. Universidad de Buenos Aires; Argentina
dc.journal.title
Domestic Animal Endocrinology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0739724020301260
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.domaniend.2020.106559
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