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dc.contributor.author
Bellia, Fabio  
dc.contributor.author
Fernandez, Macarena Soledad  
dc.contributor.author
Fabio, Maria Carolina  
dc.contributor.author
Pucci, Mariangela  
dc.contributor.author
Pautassi, Ricardo Marcos  
dc.contributor.author
D’Addario, Claudio  
dc.date.available
2021-09-09T18:33:45Z  
dc.date.issued
2020-07  
dc.identifier.citation
Bellia, Fabio; Fernandez, Macarena Soledad; Fabio, Maria Carolina; Pucci, Mariangela; Pautassi, Ricardo Marcos; et al.; Selective alterations in endogenous opioid system genes expression in rats selected for high ethanol intake during adolescence; Elsevier Ireland; Drug And Alcohol Dependence; 212; 7-2020; 1-9  
dc.identifier.issn
0376-8716  
dc.identifier.uri
http://hdl.handle.net/11336/140032  
dc.description.abstract
Historically, the roots of alcoholism have been linked to either environment or heredity. However, the interaction between these factors is still largely unexplored. The evidence supports a link between alcohol consumption and the endogenous opioid system. We here studied the opioid genes expression in male and female Wistar rats derived from a short-term breeding program which selected -- at adolescence -- for high (ADHI line) or low (ADLO line) ethanol drinking. Specifically, in this work we analyzed central opioid gene expression in the rats of the second filial generation (S2-ADLO and S2-ADHI). Selective downregulation of pronociceptin (Pnoc) and its receptor (Oprl1) mRNA levels were observed in the prefrontal cortex of male S2-ADHI rats when compared to S2-ADLO, and for Oprl1 also in the nucleus accumbens. An increase in gene expression was instead observed for pro-opiomelanocortin (Pomc) in the nucleus accumbens of S2-ADHI males when compared to S2-ADLO, as well as for mu opioid receptor (Oprm1) but in females. The differences in mRNA levels may be due to the different alcohol consumption between the two groups of rats or may represent pre-existing differences between them. Moreover, we show a sex-specific modulation of the expression of these genes, thus pointing out the importance of sex on ethanol responses. The results might lead to more specific and effective pharmacological treatments for alcoholism.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Ireland  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
ADOLESCENCE  
dc.subject
ALCOHOL  
dc.subject
GENE EXPRESSION  
dc.subject
OPIOID SYSTEM  
dc.subject
RAT  
dc.subject.classification
Drogadicción  
dc.subject.classification
Ciencias de la Salud  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Selective alterations in endogenous opioid system genes expression in rats selected for high ethanol intake during adolescence  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-04-23T18:34:42Z  
dc.journal.volume
212  
dc.journal.pagination
1-9  
dc.journal.pais
Irlanda  
dc.journal.ciudad
Shannon  
dc.description.fil
Fil: Bellia, Fabio. Università degli Studi di Teramo; Italia  
dc.description.fil
Fil: Fernandez, Macarena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina  
dc.description.fil
Fil: Fabio, Maria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina  
dc.description.fil
Fil: Pucci, Mariangela. Università degli Studi di Teramo; Italia  
dc.description.fil
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina  
dc.description.fil
Fil: D’Addario, Claudio. Università degli Studi di Teramo; Italia. Karolinska Huddinge Hospital; Suecia  
dc.journal.title
Drug And Alcohol Dependence  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0376871620301903  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.drugalcdep.2020.108025