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dc.contributor.author Cicora, Federico
dc.contributor.author Stringa, Pablo Luis
dc.contributor.author Guerrieri, Diego
dc.contributor.author Vásquez, Daniela
dc.contributor.author Toniolo, Fernanda
dc.contributor.author Roberti, Javier
dc.contributor.author Raimondi, Clemente
dc.date.available 2017-03-16T19:35:03Z
dc.date.issued 2013-06
dc.identifier.citation Cicora, Federico; Stringa, Pablo Luis; Guerrieri, Diego; Vásquez, Daniela; Toniolo, Fernanda; et al.; Evaluation of histological damage of solid organs after donor preconditioning with thymoglobulin in an experimental rat model; Elsevier Science; Transplant Immunology; 28; 4; 6-2013; 203-205
dc.identifier.issn 0966-3274
dc.identifier.uri http://hdl.handle.net/11336/13994
dc.description.abstract Rabbit anti-rat thymoglobulin (rATG) administered to donors with brain death (BD) may improve organs quality. We explored the effects of rATG administered to BD donors in the histology of heart, lungs and small bowel in a rat experimental model. Animals were randomly assigned to 3 groups: V (n = 5) no BD, 2 h ventilation; BD (n = 5) BD and 2 h ventilation; BD and rATG: BD, 2 h ventilation, rATG (10 mg/kg) after BD diagnosis. Histopathological damage scores were based on neutrophil infiltration, airway epithelial cell damage, interstitial edema, hyaline membrane formation, and pulmonary hemorrhage (lungs); neutrophil infiltration and interstitial edema (heart); Park score (bowel). Lung damage was significantly lower in BD + rATG group: V 5 ± 1.6; BD 11.25 ± 0.5, BD + rATG 6.5 ± 1.9 (p < 0.01). Heart: V 2.0 ± 0.81; BD 4.75 ± 1.25 and BD + rATG 3.5 ± 1.7 (p > 0.05). Small bowel: BD 2.25 ± 0.96 vs. BD + rATG 1.00 ± 1.15 (n.s.). Histological damage amelioration in lung and attenuation tendency in heart and small bowel encourages research of cytoprotective strategies to improve organ viability.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier Science
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject transplantation
dc.subject donor preconditioning
dc.subject animal model
dc.subject thymoglobulin
dc.subject brain death
dc.subject.classification Inmunología
dc.subject.classification Medicina Básica
dc.subject.classification CIENCIAS MÉDICAS Y DE LA SALUD
dc.title Evaluation of histological damage of solid organs after donor preconditioning with thymoglobulin in an experimental rat model
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2017-03-06T15:25:08Z
dc.journal.volume 28
dc.journal.number 4
dc.journal.pagination 203-205
dc.journal.pais Países Bajos
dc.journal.ciudad Ámsterdam
dc.description.fil Fil: Cicora, Federico. Foundation for Research & Assistance in Kidney Disease; Argentina. Hospital Alemán; Argentina
dc.description.fil Fil: Stringa, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata; Argentina
dc.description.fil Fil: Guerrieri, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil Fil: Vásquez, Daniela. Foundation for Research & Assistance in Kidney Disease; Argentina
dc.description.fil Fil: Toniolo, Fernanda. Universidad Nacional de La Plata; Argentina
dc.description.fil Fil: Roberti, Javier. Foundation for Research & Assistance in Kidney Disease; Argentina
dc.description.fil Fil: Raimondi, Clemente. Universidad Nacional de La Plata; Argentina
dc.journal.title Transplant Immunology
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S096632741300021X
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.trim.2013.04.002


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)