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dc.contributor.author
Cicora, Federico
dc.contributor.author
Stringa, Pablo Luis
dc.contributor.author
Guerrieri, Diego
dc.contributor.author
Vásquez, Daniela
dc.contributor.author
Toniolo, Fernanda
dc.contributor.author
Roberti, Javier
dc.contributor.author
Raimondi, Clemente
dc.date.available
2017-03-16T19:35:03Z
dc.date.issued
2013-06
dc.identifier.citation
Cicora, Federico; Stringa, Pablo Luis; Guerrieri, Diego; Vásquez, Daniela; Toniolo, Fernanda; et al.; Evaluation of histological damage of solid organs after donor preconditioning with thymoglobulin in an experimental rat model; Elsevier Science; Transplant Immunology; 28; 4; 6-2013; 203-205
dc.identifier.issn
0966-3274
dc.identifier.uri
http://hdl.handle.net/11336/13994
dc.description.abstract
Rabbit anti-rat thymoglobulin (rATG) administered to donors with brain death (BD) may improve organs quality. We explored the effects of rATG administered to BD donors in the histology of heart, lungs and small bowel in a rat experimental model. Animals were randomly assigned to 3 groups: V (n = 5) no BD, 2 h ventilation; BD (n = 5) BD and 2 h ventilation; BD and rATG: BD, 2 h ventilation, rATG (10 mg/kg) after BD diagnosis. Histopathological damage scores were based on neutrophil infiltration, airway epithelial cell damage, interstitial edema, hyaline membrane formation, and pulmonary hemorrhage (lungs); neutrophil infiltration and interstitial edema (heart); Park score (bowel). Lung damage was significantly lower in BD + rATG group: V 5 ± 1.6; BD 11.25 ± 0.5, BD + rATG 6.5 ± 1.9 (p < 0.01). Heart: V 2.0 ± 0.81; BD 4.75 ± 1.25 and BD + rATG 3.5 ± 1.7 (p > 0.05). Small bowel: BD 2.25 ± 0.96 vs. BD + rATG 1.00 ± 1.15 (n.s.). Histological damage amelioration in lung and attenuation tendency in heart and small bowel encourages research of cytoprotective strategies to improve organ viability.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Transplantation
dc.subject
Donor Preconditioning
dc.subject
Animal Model
dc.subject
Thymoglobulin
dc.subject
Brain Death
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Evaluation of histological damage of solid organs after donor preconditioning with thymoglobulin in an experimental rat model
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-06T15:25:08Z
dc.journal.volume
28
dc.journal.number
4
dc.journal.pagination
203-205
dc.journal.pais
Países Bajos
dc.journal.ciudad
Ámsterdam
dc.description.fil
Fil: Cicora, Federico. Foundation for Research & Assistance in Kidney Disease; Argentina. Hospital Alemán; Argentina
dc.description.fil
Fil: Stringa, Pablo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata; Argentina
dc.description.fil
Fil: Guerrieri, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Vásquez, Daniela. Foundation for Research & Assistance in Kidney Disease; Argentina
dc.description.fil
Fil: Toniolo, Fernanda. Universidad Nacional de La Plata; Argentina
dc.description.fil
Fil: Roberti, Javier. Foundation for Research & Assistance in Kidney Disease; Argentina
dc.description.fil
Fil: Raimondi, Clemente. Universidad Nacional de La Plata; Argentina
dc.journal.title
Transplant Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S096632741300021X
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.trim.2013.04.002


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