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dc.contributor.author
Torres, María Luz
dc.contributor.author
Oberti, Tamara Gisela
dc.contributor.author
Fernández, Juan Manuel
dc.date.available
2021-09-08T18:53:39Z
dc.date.issued
2020-11-12
dc.identifier.citation
Torres, María Luz; Oberti, Tamara Gisela; Fernández, Juan Manuel; HEMA and alginate-based chondrogenic semi-interpenetrated hydrogels: Synthesis and biological bharacterization; Taylor & Francis; Journal of Biomaterials Science - Polymer Edition; 32; 4; 12-11-2020; 504-523
dc.identifier.issn
0920-5063
dc.identifier.uri
http://hdl.handle.net/11336/139939
dc.description.abstract
Cartilage tissue engineering (CTE) has the general objective of restoring and improving damaged cartilage. A very interesting strategy of CTE is to combine different polymers to obtain a viscoelastic material. In the present study we have evaluated the applicability of Poly(2-hydroxyethyl methacrylate) networks semi-interpenetrated with sodium alginate for CTE. Alginate-containing hydrogels show an increase in scaffold porosity and swelling capacity, when compared with nonporous poly(2-hydroxyethyl methacrylate) scaffolds. Primary chondrocytes from young rats were cultured on the hydrogels, and an increase in chondrocyte proliferation and chondrocytic markers was observed in alginate-containing hydrogels. Chondrocytic phenotype was preserved on hydrogels containing the lowest amount of crosslinker and initiator (SEMI 3 and SEMI 4). In addition, Nitric oxide production by RAW264.7 macrophages grown on hydrogels was tested and none of the hydrogels showed high levels of this inflammatory marker after 2 days. These results indicate that our alginate-containing hydrogels could be useful for CTE.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
SEMI-INTERPENETRATING POLYMER NETWORK
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CHONDROCYTE
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CHONDROCOMPATIBILITY
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SWELLING
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CONTACT ANGLE
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Otras Ingeniería Médica
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Ingeniería Médica
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
HEMA and alginate-based chondrogenic semi-interpenetrated hydrogels: Synthesis and biological bharacterization
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-09-06T17:07:39Z
dc.journal.volume
32
dc.journal.number
4
dc.journal.pagination
504-523
dc.journal.pais
Países Bajos
dc.description.fil
Fil: Torres, María Luz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación en Osteospatías y Metabolismo Mineral; Argentina
dc.description.fil
Fil: Oberti, Tamara Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
dc.description.fil
Fil: Fernández, Juan Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigación en Osteospatías y Metabolismo Mineral; Argentina
dc.journal.title
Journal of Biomaterials Science - Polymer Edition
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.1080/09205063.2020.1849920
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1080/09205063.2020.1849920
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