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dc.contributor.author
Studdert, Claudia Alicia  
dc.contributor.author
Parkinson, John S.  
dc.date.available
2021-09-06T21:03:23Z  
dc.date.issued
2007-12  
dc.identifier.citation
Studdert, Claudia Alicia; Parkinson, John S.; In Vivo Crosslinking Methods for Analyzing the Assembly and Architecture of Chemoreceptor Arrays; Elsevier Academic Press Inc.; Methods In Enzymology; 423; 12-2007; 414-431  
dc.identifier.issn
0076-6879  
dc.identifier.uri
http://hdl.handle.net/11336/139753  
dc.description.abstract
The chemoreceptor molecules that mediate chemotactic responses in bacteria and archaea are physically clustered and operate as highly cooperative arrays. Few experimental approaches are able to investigate the structure-function organization of these chemoreceptor networks in living cells. This chapter describes chemical crosslinking methods that can be applied under normal physiological conditions to explore physical interactions between chemoreceptors and their underlying genetic and structural basis. Most of these crosslinking approaches are based on available atomic structures for chemoreceptor homodimers, the fundamental building block for higher-order networks. However, the general logic of our in vivo crosslinking approaches is readily applicable to other protein-protein interactions and other organisms, even when high-resolution structural information is not available.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Academic Press Inc.  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CHEMORECEPTORS  
dc.subject
IN VIVOCROSSLINKING  
dc.subject.classification
Biología Celular, Microbiología  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
In Vivo Crosslinking Methods for Analyzing the Assembly and Architecture of Chemoreceptor Arrays  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-08-30T14:39:23Z  
dc.journal.volume
423  
dc.journal.pagination
414-431  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Burlington  
dc.description.fil
Fil: Studdert, Claudia Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones Biológicas. Universidad Nacional de Mar del Plata. Facultad de Ciencias Exactas y Naturales. Instituto de Investigaciones Biológicas; Argentina  
dc.description.fil
Fil: Parkinson, John S.. No especifíca;  
dc.journal.title
Methods In Enzymology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0076687907230198  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/S0076-6879(07)23019-8