Artículo
Heterologous Production of Polyketides in Bacteria
Fecha de publicación:
01/2009
Editorial:
Elsevier Academic Press Inc.
Revista:
Methods In Enzymology
ISSN:
0076-6879
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Polyketide natural products are among the most important microbial metabolites in human medicine and are widely used to treat both acute and degenerative diseases. The need to develop new drugs has prompted the idea of using heterologous systems for the expression of polyketide biosynthetic pathways. The basic idea behind this approach is to use heterologous bacterial systems with better growth and genetic characteristics that could support better production of a certain compound than the original host or that could allow the generation of novel analogues through combinatorial biosynthesis. Moreover, these hosts could be used to express "cryptic" secondary metabolic pathways or serve as surrogate hosts in metagenomics experiments in order to find potential new bioactive compounds. In this chapter we discuss recent advances in the heterologous production of polyketides in bacteria and describe some methodological improvements of the systems.
Palabras clave:
SYNTHETIC BIOLOGY
,
PROTEIN ENGINEERING
,
COMBINATORIAL BIOSYNTHESIS
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Articulos(IBR)
Articulos de INST.DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Articulos de INST.DE BIOLOGIA MOLECULAR Y CELULAR DE ROSARIO
Citación
Rodriguez, Eduardo Jose; Menzella, Hugo Gabriel; Gramajo, Hugo Cesar; Heterologous Production of Polyketides in Bacteria; Elsevier Academic Press Inc.; Methods In Enzymology; 459; B; 1-2009; 339-365
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