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dc.contributor.author
Jalalvand, Ali R.  
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Ghobadi, Sirous  
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Akbari, Vali  
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Goicoechea, Hector Casimiro  
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Faramarzi, Elahe  
dc.contributor.author
Mahmoudi, Majid  
dc.date.available
2021-09-03T13:01:04Z  
dc.date.issued
2019-09  
dc.identifier.citation
Jalalvand, Ali R.; Ghobadi, Sirous; Akbari, Vali; Goicoechea, Hector Casimiro; Faramarzi, Elahe; et al.; Mathematical modeling of interactions of cabergoline with human serum albumin for biosensing of human serum albumin; Elsevier; Sensing and Bio-Sensing Research; 25; 9-2019; 1-12; 100297  
dc.identifier.uri
http://hdl.handle.net/11336/139627  
dc.description.abstract
In this work, we are going to study the interactions of cabergoline (CBG) with human serum albumin (HSA) by mathematical modeling of voltammetric and spectroscopic data. To achieve this goal, voltammetric and spectroscopic data will be augmented into a data matrix which will be resolved by multivariate curve resolution-alternating least squares (MCR-ALS) as a powerful chemometric tool. Then, the quality of the data fitting by MCR-ALS will be examined by MCR-BANDS to ensure about the absence of the rotational ambiguities in the results. Molecular docking will also be used to model the interactions of CBG with HSA for verifying the results obtained from experimental methods. Hard-modeling of the experimental data will be performed by EQUISPEC to compute the binding constant of the complex formed from the interactions of CBG with HSA for verifying the binding constant obtained by direct analysis of the experimental data. Finally, two chrono-amperometric measurements based on CBG-HSA interactions will be performed to develop a novel electroanalytical method for determination of electro-inactive HSA.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
CABERGOLINE  
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DETERMINATION  
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HUMAN SERUM ALBUMIN  
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INTERACTIONS  
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MULTIVARIATE ANALYSIS  
dc.subject.classification
Química Analítica  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Mathematical modeling of interactions of cabergoline with human serum albumin for biosensing of human serum albumin  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-11-27T18:47:41Z  
dc.identifier.eissn
2214-1804  
dc.journal.volume
25  
dc.journal.pagination
1-12; 100297  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Jalalvand, Ali R.. Kermanshah University of Medical Sciences; Irán  
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Fil: Ghobadi, Sirous. Razi University; Irán  
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Fil: Akbari, Vali. Razi University; Irán. Kermanshah University of Medical Sciences; Irán  
dc.description.fil
Fil: Goicoechea, Hector Casimiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Desarrollo Analítico y Quimiometría; Argentina  
dc.description.fil
Fil: Faramarzi, Elahe. Kermanshah University of Medical Sciences; Irán  
dc.description.fil
Fil: Mahmoudi, Majid. Kermanshah University of Medical Sciences; Irán  
dc.journal.title
Sensing and Bio-Sensing Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.sbsr.2019.100297  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2214180419300972