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dc.contributor.author
Jalalvand, Ali R.
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dc.contributor.author
Ghobadi, Sirous
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dc.contributor.author
Akbari, Vali
dc.contributor.author
Goicoechea, Hector Casimiro
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dc.contributor.author
Faramarzi, Elahe
dc.contributor.author
Mahmoudi, Majid
dc.date.available
2021-09-03T13:01:04Z
dc.date.issued
2019-09
dc.identifier.citation
Jalalvand, Ali R.; Ghobadi, Sirous; Akbari, Vali; Goicoechea, Hector Casimiro; Faramarzi, Elahe; et al.; Mathematical modeling of interactions of cabergoline with human serum albumin for biosensing of human serum albumin; Elsevier; Sensing and Bio-Sensing Research; 25; 9-2019; 1-12; 100297
dc.identifier.uri
http://hdl.handle.net/11336/139627
dc.description.abstract
In this work, we are going to study the interactions of cabergoline (CBG) with human serum albumin (HSA) by mathematical modeling of voltammetric and spectroscopic data. To achieve this goal, voltammetric and spectroscopic data will be augmented into a data matrix which will be resolved by multivariate curve resolution-alternating least squares (MCR-ALS) as a powerful chemometric tool. Then, the quality of the data fitting by MCR-ALS will be examined by MCR-BANDS to ensure about the absence of the rotational ambiguities in the results. Molecular docking will also be used to model the interactions of CBG with HSA for verifying the results obtained from experimental methods. Hard-modeling of the experimental data will be performed by EQUISPEC to compute the binding constant of the complex formed from the interactions of CBG with HSA for verifying the binding constant obtained by direct analysis of the experimental data. Finally, two chrono-amperometric measurements based on CBG-HSA interactions will be performed to develop a novel electroanalytical method for determination of electro-inactive HSA.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CABERGOLINE
dc.subject
DETERMINATION
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HUMAN SERUM ALBUMIN
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INTERACTIONS
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MULTIVARIATE ANALYSIS
dc.subject.classification
Química Analítica
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Mathematical modeling of interactions of cabergoline with human serum albumin for biosensing of human serum albumin
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-27T18:47:41Z
dc.identifier.eissn
2214-1804
dc.journal.volume
25
dc.journal.pagination
1-12; 100297
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Jalalvand, Ali R.. Kermanshah University of Medical Sciences; Irán
dc.description.fil
Fil: Ghobadi, Sirous. Razi University; Irán
dc.description.fil
Fil: Akbari, Vali. Razi University; Irán. Kermanshah University of Medical Sciences; Irán
dc.description.fil
Fil: Goicoechea, Hector Casimiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Desarrollo Analítico y Quimiometría; Argentina
dc.description.fil
Fil: Faramarzi, Elahe. Kermanshah University of Medical Sciences; Irán
dc.description.fil
Fil: Mahmoudi, Majid. Kermanshah University of Medical Sciences; Irán
dc.journal.title
Sensing and Bio-Sensing Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.sbsr.2019.100297
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2214180419300972
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