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dc.contributor.author
Jalalvand, Ali R.  
dc.contributor.author
Ghobadi, Sirous  
dc.contributor.author
Goicoechea, Hector Casimiro  
dc.contributor.author
Faramarzi, Elahe  
dc.contributor.author
Mahmoudi, Majid  
dc.date.available
2021-09-03T12:58:01Z  
dc.date.issued
2019-07  
dc.identifier.citation
Jalalvand, Ali R.; Ghobadi, Sirous; Goicoechea, Hector Casimiro; Faramarzi, Elahe; Mahmoudi, Majid; Matrix augmentation as an efficient method for resolving interaction of bromocriptine with human serum albumin: trouble shooting and simultaneous resolution; Elsevier; Heliyon; 5; 7; 7-2019; 1-11; e02153  
dc.identifier.issn
2405-8440  
dc.identifier.uri
http://hdl.handle.net/11336/139624  
dc.description.abstract
This work reports the results of an interesting study related to the investigation of interactions of bromocriptine (BCP) with human serum albumin (HSA) by mathematicall modelling of voltammetric and spectroscopic data into an augmented data matrix and its resolution by multivariate curve resolution-alternating least squares (MCR-ALS). The quality of the results obtained by MCR-ALS was examined by MCR-BANDS and its outputs confirmed the absence of rotational ambiguities in the MCR-ALS results. BCP-HSA interactions were also modeled by molecular docking methods to verify the results obtained from experimental sections and fortunately, they were compatible. Hard modeling of the experimental data by EQUISPEC helped us to calculate the binding constant of the complex formed from BCP-HSA interactions which was in a good agreement with that of calculated from direct analysis of the experimental data. Finally, with the help of two different amperometric measurements based on BCP-HSA interactions a novel electroanalytical method was developed for biosensing of HSA in serum samples.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
ANALYTICAL CHEMISTRY  
dc.subject
BROMOCRIPTINE  
dc.subject
ELECTROCHEMISTRY  
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HUMAN SERUM ALBUMIN  
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INTERACTIONS  
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MATRIX AUGMENTATION  
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PHARMACEUTICAL CHEMISTRY  
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THEORETICAL CHEMISTRY  
dc.subject.classification
Química Analítica  
dc.subject.classification
Ciencias Químicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Matrix augmentation as an efficient method for resolving interaction of bromocriptine with human serum albumin: trouble shooting and simultaneous resolution  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-11-27T18:48:56Z  
dc.journal.volume
5  
dc.journal.number
7  
dc.journal.pagination
1-11; e02153  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Jalalvand, Ali R.. Kermanshah University of Medical Sciences; Irán  
dc.description.fil
Fil: Ghobadi, Sirous. Kermanshah University of Medical Sciences; Irán  
dc.description.fil
Fil: Goicoechea, Hector Casimiro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Desarrollo Analítico y Quimiometría; Argentina  
dc.description.fil
Fil: Faramarzi, Elahe. Kermanshah University of Medical Sciences; Irán  
dc.description.fil
Fil: Mahmoudi, Majid. Kermanshah University of Medical Sciences; Irán  
dc.journal.title
Heliyon  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/heliyon/fulltext/S2405-8440(19)35813-X  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.heliyon.2019.e02153