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dc.contributor.author
de Cavanagh, E. M. V.
dc.contributor.author
Piotrkowski, Barbara
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dc.contributor.author
Fraga, César Guillermo
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dc.date.available
2021-09-02T15:25:22Z
dc.date.issued
2007-12
dc.identifier.citation
de Cavanagh, E. M. V.; Piotrkowski, Barbara; Fraga, César Guillermo; The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: A hypothesis including the participation of mitochondria in aging; Frontiers in Bioscience; Frontiers in Bioscience; 12; 3; 12-2007; 1049-1062
dc.identifier.issn
1093-9946
dc.identifier.uri
http://hdl.handle.net/11336/139547
dc.description.abstract
The objective of improving health is intimately associated with preventing and delaying age-related diseases. Nutritional and pharmacological approaches aimed at retarding aging are uncovering mechanisms, whose definitive roles in cell and tissue physiology need to be defined. In this article we hypothesize that peroxisome proliferator activated receptor (PPAR)-modulation is a pivotal process that underlies the association between mitochondria and the renin-angiotensin system (RAS) in aging. This hypothesis is based on several lines of evidence suggesting that: a) mitochondrial function and oxidant production are active participants in the aging process; b) PPARs, by regulating mitochondrial function and uncoupling proteins (UCP), seem to play a major role in the age-retarding effects of caloric restriction; c) RAS inhibition delays the deleterious effects of aging and also upregulates PPARs; and d) a number of physiological and molecular events that occur in experimental caloric restriction, and experimental and clinical RAS inhibition, involve changes in mitochondrial functions.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Frontiers in Bioscience
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANGIOTENSIN
dc.subject
MITOCHONDRIA
dc.subject
OXIDATIVE DAMAGE
dc.subject
RESPIRATORY CHAIN
dc.subject
REVIEW
dc.subject.classification
Biofísica
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
The interaction between the renin-angiotensin system and peroxisome proliferator activated receptors: A hypothesis including the participation of mitochondria in aging
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-07-26T17:12:59Z
dc.journal.volume
12
dc.journal.number
3
dc.journal.pagination
1049-1062
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
New York
dc.description.fil
Fil: de Cavanagh, E. M. V.. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Piotrkowski, Barbara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Fraga, César Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.journal.title
Frontiers in Bioscience
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2741/2125
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://fbscience.com/Landmark/articles/10.2741/2125
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