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dc.contributor.author
Islan, German Abel  
dc.contributor.author
Gonçalves, Lídia M. D.  
dc.contributor.author
Marto, Joana  
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Duarte, Aida  
dc.contributor.author
Alvarez, Vera Alejandra  
dc.contributor.author
Castro, Guillermo Raul  
dc.contributor.author
Almeida, António J.  
dc.date.available
2021-09-02T12:39:29Z  
dc.date.issued
2021-01  
dc.identifier.citation
Islan, German Abel; Gonçalves, Lídia M. D.; Marto, Joana; Duarte, Aida; Alvarez, Vera Alejandra; et al.; Effect of α-tocopherol on the physicochemical, antioxidant and antibacterial properties of levofloxacin loaded hybrid lipid nanocarriers; Royal Society of Chemistry; New Journal of Chemistry; 45; 2; 1-2021; 1029-1042  
dc.identifier.issn
1144-0546  
dc.identifier.uri
http://hdl.handle.net/11336/139512  
dc.description.abstract
In the global context of emerging pathogens associated with respiratory diseases, novel nanostructured lipid carriers (NLCs) having both antioxidant and antimicrobial properties produced by α-tocopherol (αT) and levofloxacin (LV), respectively, were developed. The hybrid NLCs were made of solid lipid esters and liquid αT as the central core, plus chitosan (Chi) and poloxamer 188 as surface stabilizers. Three formulations were rationally designed considering lipids with different physicochemical properties: cetyl ester (SS), glyceryl dibehenate (CO) and glyceryl tristearate (DY). The properties and stability of the nanoformulations were studied by dynamic light scattering considering the effects of the homogenization time, surfactant concentration, and initial lipid amount on the mean size, polydispersity index (PDI) and zeta potential of the nanoparticles. The effect of αT on the nanostructuration of the lipid matrix was demonstrated by X-ray diffraction, differential scanning calorimetry, and thermogravimetry analysis. The potential ability of the NLCs to interact with the mucosa was studied by rheological methods, demonstrating a reduction in mucin cohesiveness and elasticity due to the mucoadhesive properties of NLCs coated with chitosan. Solid lipid nanoparticles (SLNs) of SS, CO and DY encapsulated 58.0 ± 3.2, 25.7 ± 7.1, and 27.9 ± 1.5% LV, respectively, while the NLC formulations were able to encapsulate 80-90% LV and allowed controlled release of the drug. The enhanced antimicrobial properties of the SLNs/NLCs against Pseudomonas aeruginosa and Staphylococcus aureus were confirmed. The presence of αT in the formulations provided the antioxidant properties of the NLCs. Finally, no acute toxicities of the formulations were observed in two human lung cell lines (A549 and Calu-3).  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Royal Society of Chemistry  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Tocopherol  
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Antioxidant  
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Antibacterial  
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SLN  
dc.subject.classification
Otras Ingeniería de los Materiales  
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Ingeniería de los Materiales  
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INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Effect of α-tocopherol on the physicochemical, antioxidant and antibacterial properties of levofloxacin loaded hybrid lipid nanocarriers  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-08-19T20:31:42Z  
dc.journal.volume
45  
dc.journal.number
2  
dc.journal.pagination
1029-1042  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Cambridge  
dc.description.fil
Fil: Islan, German Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina  
dc.description.fil
Fil: Gonçalves, Lídia M. D.. Universidade Nova de Lisboa; Portugal  
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Fil: Marto, Joana. Universidade Nova de Lisboa; Portugal  
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Fil: Duarte, Aida. Universidade Nova de Lisboa; Portugal  
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Fil: Alvarez, Vera Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina  
dc.description.fil
Fil: Castro, Guillermo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Fermentaciones Industriales. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Fermentaciones Industriales; Argentina  
dc.description.fil
Fil: Almeida, António J.. Universidade Nova de Lisboa; Portugal  
dc.journal.title
New Journal of Chemistry  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://xlink.rsc.org/?DOI=D0NJ03781H  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/D0NJ03781H