Artículo
Efficacy and Safety of Albendazole and High-Dose Ivermectin Coadministration in School-Aged Children Infected With Trichuris trichiura in Honduras: A Randomized Controlled Trial
Matamoros, Gabriela; Sánchez, Ana; Gabrie, José Antonio; Juárez, Marisa; Ceballos, Laura
; Escalada, Andrés; Rodríguez, Carol; Martí Soler, Helena; Rueda, María Mercedes; Canales, Maritza; Lanusse, Carlos Edmundo
; Cajal, Silvana Pamela; Alvarez, Luis Ignacio
; Cimino, Rubén Oscar
; Krolewiecki, Alejandro Javier
Fecha de publicación:
04/2021
Editorial:
University of Chicago Press
Revista:
Clinical Infectious Diseases
ISSN:
1058-4838
e-ISSN:
1537-6591
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Background: The efficacy of currently available anthelminthics against Trichuris trichiura infections is significatively lower than for other soil-transmitted helminths (STH). The combination of ivermectin (IVM) and albendazole (ALB) has shown significant improvements in efficacy.Methods: Safety and efficacy randomized controlled clinical trial comparing 3 experimental regimens against ALB monotherapy for the treatment of T. trichiura infections in northern Honduras. Infected children were randomized to one of the following treatments: (Arm 1) single-dose ALB 400 mg; (Arm 2) single-dose ALB 400 mg/IVM 600 μg/kg; (Arm 3) ALB 400 mg for 3 consecutive days; or (Arm 4) ALB 400 mg/IVM 600 μg/kg for 3 consecutive days. Efficacy was measured through egg reduction rate (ERR) and cure rate (CR), both assessed 14-21 days after treatment using the Kato-Katz method. Safety was evaluated by analyzing the frequency and severity of adverse events.Results: A total of 176 children were randomized to one of the 4 treatment arms, 117 completed treatment and follow-up. The ERR for Arms 1 to 4 were: 47.7%, 96.7%, 72.1% and 100%, respectively; with p-values <0.001 between IVM groups and ALB only arms. The CRs were 4.2%, 88.6%, 33.3% and 100%, respectively. A total of 48 (85.4% mild) AEs were reported in 36 children.Conclusions: The combined use of ALB and high-dose IVM is a highly effective and well tolerated treatment for the treatment of T. trichiura infections offering a significantly improved treatment for the control of this infection.
Palabras clave:
TRICHURIS
,
ALBENDAZOLE
,
IVERMECTIN
,
ANTHELMINTIC
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Articulos(CCT - SALTA-JUJUY)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SALTA-JUJUY
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SALTA-JUJUY
Articulos(CIVETAN)
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Citación
Matamoros, Gabriela; Sánchez, Ana; Gabrie, José Antonio; Juárez, Marisa; Ceballos, Laura; et al.; Efficacy and Safety of Albendazole and High-Dose Ivermectin Coadministration in School-Aged Children Infected With Trichuris trichiura in Honduras: A Randomized Controlled Trial; University of Chicago Press; Clinical Infectious Diseases; 2021; 4-2021; 1-22
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