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dc.contributor.author
Blanco, Guillermo Armando C.
dc.date.available
2017-03-15T21:28:49Z
dc.date.issued
2010-09
dc.identifier.citation
Blanco, Guillermo Armando C.; Cell death and the immune response of the sipunculid worm Themiste petricola; University of Modena and Reggio Emilia; Invertebrate Survival Journal; 7; 9-2010; 239-250
dc.identifier.issn
1824-307X
dc.identifier.uri
http://hdl.handle.net/11336/13940
dc.description.abstract
We have recently studied the role of cell death in the immune system of the sipunculan worm Themiste petricola. Typical biochemical and morphological changes of apoptosis were induced in celomocytes of these marine worms after in vitro exposure of cells to hydrogen peroxide. Apoptosis was time and dose dependent, and required several hours to become apparent. Surprisingly, in unexposed samples a subtype of granulocyte was observed to undergo homotypic aggregation, extensive cytoskeletal changes, and degranulation followed by cell death. This spontaneous response ending in cell death occurred in a divalent cation-dependent manner, served to entrap foreign particles, and was blocked by EDTA-containing saline solutions. Even though the mode of granulocyte cell death shares some features with apoptosis, it appears to be a different form of programmed cell death since it occurs within minutes and does not produce single cell-derived apoptotic bodies but transforms itself into one or several syncytial masses with haemostatic and immune purposes. Since numerous granulocyte types and multicellular masses involved in cellular immunity have been described in sipunculan worms, the review also discusses the potential influence of activation of granulocytes by sea water in expanding the variety of morphological types and multicellular structures identified through morphological studies among sipunculan species.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
University of Modena and Reggio Emilia
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Sipuncula
dc.subject
Immune Responses
dc.subject
Hemostasis
dc.subject
Cell Death
dc.subject
Celomocytes
dc.subject
Apoptosis
dc.subject
Coagulation
dc.subject.classification
Biología Celular, Microbiología
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Cell death and the immune response of the sipunculid worm Themiste petricola
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-14T15:02:33Z
dc.journal.number
7
dc.journal.pagination
239-250
dc.journal.pais
Italia
dc.description.fil
Fil: Blanco, Guillermo Armando C.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
dc.journal.title
Invertebrate Survival Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.isj.unimo.it/vol7issue2.htm
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.isj.unimo.it/articoli/ISJ220.pdf


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  • Articulos(IDEHU) [124]
    Articulos de INST.DE EST.DE LA INMUNIDAD HUMORAL PROF.R.A.MARGNI

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