Artículo
Synthesis and conformational analysis of His-Phe-Arg-Trp-NH2 and analogues with antifungal properties
Masman, Marcelo Fabricio
; Rodriguez, Ana Maria; Svetaz, Laura Andrea
; Zacchino, Susana Alicia Stella; Somlai, Csaba; Csizmadia, Imre Gyula; Penke, Botond; Enriz, Ricardo Daniel
Fecha de publicación:
15/11/2006
Editorial:
Pergamon-Elsevier Science Ltd
Revista:
Bioorganic & Medicinal Chemistry
ISSN:
0968-0896
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The synthesis, in vitro evaluation, and conformational study of His-Phe-Arg-Trp-NH2 and related derivatives acting as antifungal agents are reported. Among them, His-Phe-Arg-Trp-NH2 and His-Tyr-Arg-Trp-NH2 exhibited antifungal activity against Cryptococcus neoformans. Antifungal activity of these compounds appears to be closely related to the α-MSH effect. A conformational and electronic study allows us to propose a biologically relevant conformation for these tetrapeptides acting as antifungal agents. In addition, these theoretical calculations permit us to determine the minimal structural requirements to produce the antifungal response and may provide a guide for the design of compounds with this biological activity.
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IMIBIO-SL)
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Articulos de INST. MULTIDICIPLINARIO DE INV. BIO. DE SAN LUIS
Citación
Masman, Marcelo Fabricio; Rodriguez, Ana Maria; Svetaz, Laura Andrea; Zacchino, Susana Alicia Stella; Somlai, Csaba; et al.; Synthesis and conformational analysis of His-Phe-Arg-Trp-NH2 and analogues with antifungal properties; Pergamon-Elsevier Science Ltd; Bioorganic & Medicinal Chemistry; 14; 22; 15-11-2006; 7604-7614
Compartir
Altmétricas