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dc.contributor.author
Urbano Suarez, Francisco Jose
dc.contributor.author
Bisagno, Veronica
dc.contributor.author
Garcia Rill, Edgar
dc.date.available
2021-08-27T18:47:01Z
dc.date.issued
2020-02
dc.identifier.citation
Urbano Suarez, Francisco Jose; Bisagno, Veronica; Garcia Rill, Edgar; Gamma oscillations in the pedunculopontine nucleus are regulated by F-actin: neuroepigenetic implications; American Physiological Society; American Journal of Physiology-cell Physiology; 318; 2; 2-2020; C282-C288
dc.identifier.issn
0363-6143
dc.identifier.uri
http://hdl.handle.net/11336/139129
dc.description.abstract
The pedunculopontine nucleus (PPN) is part of the reticular activating system (RAS) in charge of arousal and rapid eye movement sleep. The presence of high-frequency membrane oscillations in the gamma-band range in the PPN has been extensively demonstrated both in vivo and in vitro. Our group previously described histone deacetylation (HDAC) inhibition in vitro induced protein changes in F-actin cytoskeleton and intracellular Ca2+ concentration regulation proteins in the PPN. Here, we present evidence that supports the presence of a fine balance between HDAC function and calcium calmodulin kinase II-F-actin interactions in the PPN. We modified F-actin polymerization in vitro by using jasplakinolide (1 μM, a promoter of F-actin stabilization), or latrunculin-B (1 μM, an inhibitor of actin polymerization). Our results showed that shifting the balance in either direction significantly reduced PPN gamma oscillation as well as voltage-dependent calcium currents.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Physiological Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AROUSAL
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CALCIUM CHANNELS
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CALCIUM CURRENTS
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GAMMA OSCILLATIONS
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HISTONE DEACETYLATION
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NEUROEPIGENETICS
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TRICHOSTATIN A
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WAKING
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Gamma oscillations in the pedunculopontine nucleus are regulated by F-actin: neuroepigenetic implications
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-08-25T19:39:24Z
dc.journal.volume
318
dc.journal.number
2
dc.journal.pagination
C282-C288
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina
dc.description.fil
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
dc.description.fil
Fil: Garcia Rill, Edgar. University of Arkansas for Medical Sciences; Estados Unidos
dc.journal.title
American Journal of Physiology-cell Physiology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.physiology.org/doi/10.1152/ajpcell.00374.2019
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1152/ajpcell.00374.2019
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