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dc.contributor.author
Urbano Suarez, Francisco Jose  
dc.contributor.author
Bisagno, Veronica  
dc.contributor.author
Garcia Rill, Edgar  
dc.date.available
2021-08-27T18:47:01Z  
dc.date.issued
2020-02  
dc.identifier.citation
Urbano Suarez, Francisco Jose; Bisagno, Veronica; Garcia Rill, Edgar; Gamma oscillations in the pedunculopontine nucleus are regulated by F-actin: neuroepigenetic implications; American Physiological Society; American Journal of Physiology-cell Physiology; 318; 2; 2-2020; C282-C288  
dc.identifier.issn
0363-6143  
dc.identifier.uri
http://hdl.handle.net/11336/139129  
dc.description.abstract
The pedunculopontine nucleus (PPN) is part of the reticular activating system (RAS) in charge of arousal and rapid eye movement sleep. The presence of high-frequency membrane oscillations in the gamma-band range in the PPN has been extensively demonstrated both in vivo and in vitro. Our group previously described histone deacetylation (HDAC) inhibition in vitro induced protein changes in F-actin cytoskeleton and intracellular Ca2+ concentration regulation proteins in the PPN. Here, we present evidence that supports the presence of a fine balance between HDAC function and calcium calmodulin kinase II-F-actin interactions in the PPN. We modified F-actin polymerization in vitro by using jasplakinolide (1 μM, a promoter of F-actin stabilization), or latrunculin-B (1 μM, an inhibitor of actin polymerization). Our results showed that shifting the balance in either direction significantly reduced PPN gamma oscillation as well as voltage-dependent calcium currents.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
American Physiological Society  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
AROUSAL  
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CALCIUM CHANNELS  
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CALCIUM CURRENTS  
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GAMMA OSCILLATIONS  
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HISTONE DEACETYLATION  
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NEUROEPIGENETICS  
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TRICHOSTATIN A  
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WAKING  
dc.subject.classification
Neurociencias  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Gamma oscillations in the pedunculopontine nucleus are regulated by F-actin: neuroepigenetic implications  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-08-25T19:39:24Z  
dc.journal.volume
318  
dc.journal.number
2  
dc.journal.pagination
C282-C288  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Urbano Suarez, Francisco Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina  
dc.description.fil
Fil: Bisagno, Veronica. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina  
dc.description.fil
Fil: Garcia Rill, Edgar. University of Arkansas for Medical Sciences; Estados Unidos  
dc.journal.title
American Journal of Physiology-cell Physiology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.physiology.org/doi/10.1152/ajpcell.00374.2019  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1152/ajpcell.00374.2019