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dc.contributor.author
Salonia, Andrea
dc.contributor.author
Rastrelli, Giulia
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Hackett, Geoffrey
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Seminara, Stephanie B.
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Huhtaniemi, Ilpo T.
dc.contributor.author
Rey, Rodolfo Alberto
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dc.contributor.author
Hellstrom, Wayne J. G.
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Palmert, Mark R.
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Corona, Giovanni
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Dohle, Gert R.
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Khera, Mohit
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Chan, Yee-Ming
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Maggi, Mario
dc.date.available
2021-08-27T13:41:39Z
dc.date.issued
2019-05
dc.identifier.citation
Salonia, Andrea; Rastrelli, Giulia; Hackett, Geoffrey; Seminara, Stephanie B.; Huhtaniemi, Ilpo T.; et al.; Paediatric and adult-onset male hypogonadism; Nature Publishing Group; Nature Reviews Disease Primers; 5; 1; 5-2019; 1-21
dc.identifier.issn
2056-676X
dc.identifier.uri
http://hdl.handle.net/11336/139079
dc.description.abstract
The hypothalamic–pituitary–gonadal axis is of relevance in many processes related to the development, maturation and ageing of the male. Through this axis, a cascade of coordinated activities is carried out leading to sustained testicular endocrine function, with gonadal testosterone production, as well as exocrine function, with spermatogenesis. Conditions impairing the hypothalamic–pituitary–gonadal axis during paediatric or pubertal life may result in delayed puberty. Late-onset hypogonadism is a clinical condition in the ageing male combining low concentrations of circulating testosterone and specific symptoms associated with impaired hormone production. Testosterone therapy for congenital forms of hypogonadism must be lifelong, whereas testosterone treatment of late-onset hypogonadism remains a matter of debate because of unclear indications for replacement, uncertain efficacy and potential risks. This Primer focuses on a reappraisal of the physiological role of testosterone, with emphasis on the critical interpretation of the hypogonadal conditions throughout the lifespan of the male individual, with the exception of hypogonadal states resulting from congenital disorders of sex development.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANDROGENS
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AMH
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SERTOLI
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LEYDIG
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Endocrinología y Metabolismo
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Paediatric and adult-onset male hypogonadism
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-11-06T20:28:56Z
dc.identifier.eissn
2056-676X
dc.journal.volume
5
dc.journal.number
1
dc.journal.pagination
1-21
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Salonia, Andrea. Università Vita-Salute San Raffael; Italia
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Fil: Rastrelli, Giulia. University of Florence; Italia
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Fil: Hackett, Geoffrey. University of Bedfordshire; Reino Unido
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Fil: Seminara, Stephanie B.. Massachusetts General Hospital ; Department Of Medicine ; Harvard Medical School; Estados Unidos
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Fil: Huhtaniemi, Ilpo T.. University College London; Estados Unidos
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Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
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Fil: Hellstrom, Wayne J. G.. University of Tulane; Estados Unidos
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Fil: Palmert, Mark R.. University of Toronto; Canadá
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Fil: Corona, Giovanni. University of Florence; Italia
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Fil: Dohle, Gert R.. Erasmus University Medical Centre; Países Bajos
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Fil: Khera, Mohit. Baylor College of Medicine;
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Fil: Chan, Yee-Ming. Harvard Medical School; Estados Unidos
dc.description.fil
Fil: Maggi, Mario. University of Florence; Italia
dc.journal.title
Nature Reviews Disease Primers
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41572-019-0087-y
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1038/s41572-019-0087-y
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