The rs1801278 G > A polymorphism of IRS-1 is associated with metabolic syndrome in healthy nondiabetic men. Modulation by cigarette smoking status

Aims: To explore associations between IRS-1 rs1801278 G. > A polymorphism and metabolic syndrome (MS). Methods: rs1801278 G. > A was genotyped in 610 healthy Argentinian men. Results: GA carriers had lower risk of MS (OR = 0.52, P= 0.045), particularly among smokers (OR = 0.10, P= 0.006). Conclusions: rs1801278 GA carriers had lower risk of MS, especially among smokers. © 2011 Elsevier Ireland Ltd.

Palabras clave: GENETICS , INSULIN RECEPTOR SUBSTRATE-1 , INSULIN RESISTANCE , METABOLIC SYNDROME , POLYMORPHISM , SMOKING , TOBACCO

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)

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URI: http://hdl.handle.net/11336/13906

URL: http://www.sciencedirect.com/science/article/pii/S0168822711002476

DOI: http://dx.doi.org/10.1016/j.diabres.2011.05.018

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Articulos(IDEHU)
Articulos de INST.DE EST.DE LA INMUNIDAD HUMORAL PROF.R.A.MARGNI

Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY

Citación

Pérez Fernández, María Silvia; Tellechea, Mariana Lorena; Aranguren, Maria Florencia; Taverna, Mariano Javier; Rodríguez, Ricardo G.; et al.; The rs1801278 G > A polymorphism of IRS-1 is associated with metabolic syndrome in healthy nondiabetic men. Modulation by cigarette smoking status; Elsevier Ireland; Diabetes Research and Clinical Practice; 93; 3; 6-2011; e95-e97

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