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dc.contributor.author
Torres, Jazmin  
dc.contributor.author
Dhas, Namdev  
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Longhi, Marcela Raquel  
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García, Mónica Cristina  
dc.date.available
2021-08-26T13:16:52Z  
dc.date.issued
2020-11  
dc.identifier.citation
Torres, Jazmin; Dhas, Namdev; Longhi, Marcela Raquel; García, Mónica Cristina; Overcoming biological barriers with block copolymers-based self-assembled nanocarriers. Recent advances in delivery of anticancer therapeutics; Frontiers Media S.A.; Frontiers in Pharmacology; 11; 1840; 11-2020; 1-15  
dc.identifier.uri
http://hdl.handle.net/11336/138974  
dc.description.abstract
Cancer is one of the most common life-threatening illness and it is the world’s second largest cause of death. Chemotherapeutic anticancer drugs have many disadvantages, which led to the need to develop novel strategies to overcome these shortcomings. Moreover, tumors are heterogenous in nature and there are various biological barriers that assist in treatment reisistance. In this sense, nanotechnology has provided new strategies for delivery of anticancer therapeutics. Recently, delivery platforms for overcoming biological barriers raised by tumor cells and tumor-bearing hosts have been reported. Among them, amphiphilic block copolymers (ABC)-based self-assembled nanocarriers have attracted researchers worldwide owing to their unique properties. In this work, we addressed different biological barriers for effective cancer treatment along with several strategies to overcome them by using ABC‐based self-assembled nanostructures, with special emphasis in those that have the ability to act as responsive nanocarriers to internal or external environmental clues to trigger release of the payload. These nanocarriers have shown promising properties to revolutionize cancer treatment and diagnosis, but there are still challenges for their successful translation to clinical applications.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Frontiers Media S.A.  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
AMPHIPHILIC BLOCK COPOLYMERS  
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CELL UPTAKE  
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DRUG DELIVERY  
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INTRACELLULAR TRAFFICKING  
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NANOMEDICINE  
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STIMULI-RESPONSIVE NANOCARRIERS  
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TUMOR MICROENVIRONMENT BARRIERS  
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Otras Nanotecnología  
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Nanotecnología  
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INGENIERÍAS Y TECNOLOGÍAS  
dc.title
Overcoming biological barriers with block copolymers-based self-assembled nanocarriers. Recent advances in delivery of anticancer therapeutics  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2021-08-25T19:24:04Z  
dc.identifier.eissn
1663-9812  
dc.journal.volume
11  
dc.journal.number
1840  
dc.journal.pagination
1-15  
dc.journal.pais
Suiza  
dc.description.fil
Fil: Torres, Jazmin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina  
dc.description.fil
Fil: Dhas, Namdev. Nirma University. Institute Of Pharmacy; India  
dc.description.fil
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina  
dc.description.fil
Fil: García, Mónica Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina  
dc.journal.title
Frontiers in Pharmacology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphar.2020.593197/full  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fphar.2020.593197