Mostrar el registro sencillo del ítem
dc.contributor.author
Gentilini, Maria Virginia
dc.contributor.author
Nuñez, Guillermo G.
dc.contributor.author
Roux, Maria
dc.contributor.author
Venturiello, Stella Maris
dc.date.available
2017-03-15T15:56:50Z
dc.date.issued
2011-09
dc.identifier.citation
Gentilini, Maria Virginia; Nuñez, Guillermo G.; Roux, Maria; Venturiello, Stella Maris; Trichinella spiralis infection rapidly induces lung inflammatory response: the lung as the site of helminthocytotoxic activity; Elsevier Gmbh; Immunobiology.; 216; 9; 9-2011; 1054-1063
dc.identifier.issn
0171-2985
dc.identifier.uri
http://hdl.handle.net/11336/13896
dc.description.abstract
In the present work, we studied the kinetics of the appearance of different immunological parameters in the lungs during the intestinal phase of infection with Trichinella spiralis. We also evaluated the lung's role in the retention and death of this helminth in its migratory stage. To study these parameters, we used lung extracts, lung cell suspensions and rat lung tissue sections. During the intestinal phase of infection (days 0–13 post-infection, p.i.), an inflammatory response is elicited in the lungs, which reflects humoral, cellular and functional changes. These changes included an increased number of mast cells and eosinophils and the local production of IL-4, IL-5, IL-10, TNFα, IFNγ, IL-13, CCL11 and CCL28. We found hyperplasia of the bronchus-associated lymphoid tissue (BALT). Total and specific IgA, IgE, IgG1 and IgG2a were detected locally. The retention of the migratory larvae in the lung, together with the ex vivo cytotoxic capacity of the lung cells and antibodies present in the lung extracts, suggested that the lung was one of the immune defense organs against the pathogen's migration stage.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Gmbh
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Helminthocytotoxic Activity
dc.subject
Inflammation Response
dc.subject
Lung
dc.subject
Mucosal Immunology
dc.subject
Trichinella Spiralis
dc.subject.classification
Parasitología
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Trichinella spiralis infection rapidly induces lung inflammatory response: the lung as the site of helminthocytotoxic activity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-14T15:04:55Z
dc.journal.volume
216
dc.journal.number
9
dc.journal.pagination
1054-1063
dc.journal.pais
Alemania
dc.journal.ciudad
Munich
dc.description.fil
Fil: Gentilini, Maria Virginia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
dc.description.fil
Fil: Nuñez, Guillermo G.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
dc.description.fil
Fil: Roux, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina. Universidad de Buenos Aires; Argentina
dc.description.fil
Fil: Venturiello, Stella Maris. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
dc.journal.title
Immunobiology.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0171298511000428
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.imbio.2011.02.002
Archivos asociados