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dc.contributor.author
Sanz Ressel, Berenice Liyare
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dc.contributor.author
Barbeito, Claudio Gustavo
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dc.date.available
2021-08-26T01:22:55Z
dc.date.issued
2019
dc.identifier.citation
β-catenin expression during the canine epidermal development; 10th Meeting of the Latin American Society for Developmental Biology; Buenos Aires; Argentina; 2019; 62-62
dc.identifier.uri
http://hdl.handle.net/11336/138952
dc.description.abstract
β-catenin plays a central role both in the adherent intercellular junctions, as well as in the canonical Wnt signalling pathway. The study of the expression pattern of this protein during the canine epidermal development has not been performed. The purpose of this study was to evaluate the immunohistochemical expression pattern of β-catenin on canine samples of prenatal epidermis at different developmental stages using a tissue microarray. β-catenin immunostaining disclosed membrane and cytoplasmic expression in a high number of epidermal cells of the basal, spinous and granulous strata. Furthermore, samples of late stages of epidermal differentiation showed a nuclear expression of β-catenin was observed in a few cells of the granulous stratum. These results support the relevant role that β-catenin plays in the adherent intercellular junction during the normal canine epidermis development. In addition, the nuclear expression of β-catenin in a few highly differentiated granular keratinocytes during the late stages of the epidermal development could be related to the loss of adherent junctions for the stratum corneum formation. In addition, the fact that the nuclear labelling of β-catenin, which is considered a hallmark of activation of the Wnt signalling pathway, was not the dominant expression observed in the fetal epidermis suggests that this signaling pathway does not play a relevant role during the epidermal development in dogs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Latin American Society for Developmental Biology
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
β-catenin
dc.subject
Canine epidermal
dc.subject.classification
Otras Ciencias Veterinarias
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dc.subject.classification
Ciencias Veterinarias
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dc.subject.classification
CIENCIAS AGRÍCOLAS
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dc.title
β-catenin expression during the canine epidermal development
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/conferenceObject
dc.type
info:ar-repo/semantics/documento de conferencia
dc.date.updated
2021-08-25T17:42:47Z
dc.journal.pagination
62-62
dc.journal.pais
Argentina
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dc.journal.ciudad
Buenos Aires
dc.description.fil
Fil: Sanz Ressel, Berenice Liyare. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Histología y Embriología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.description.fil
Fil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Histología y Embriología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.conicet.rol
Autor
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dc.coverage
Internacional
dc.type.subtype
Reunión
dc.description.nombreEvento
10th Meeting of the Latin American Society for Developmental Biology
dc.date.evento
2019-10-28
dc.description.ciudadEvento
Buenos Aires
dc.description.paisEvento
Argentina
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dc.type.publicacion
Book
dc.description.institucionOrganizadora
Latin American Society for Developmental Biology
dc.source.libro
Talks abstracts: Latin American Society for Developmental Biology 2019
dc.date.eventoHasta
2019-10-31
dc.type
Reunión
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