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dc.contributor.author
Evans, Anne M.
dc.contributor.author
ODonovan, Claire
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Playdon, Mary
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Beecher, Chris
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Beger, Richard D.
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Bowden, John A.
dc.contributor.author
Broadhurst, David
dc.contributor.author
Clish, Clary B.
dc.contributor.author
Dasari, Surendra
dc.contributor.author
Dunn, Warwick B.
dc.contributor.author
Griffin, Julian L.
dc.contributor.author
Hartung, Thomas
dc.contributor.author
Hsu, Ping Ching
dc.contributor.author
Huan, Tao
dc.contributor.author
Jans, Judith
dc.contributor.author
Jones, Christina M.
dc.contributor.author
Kachman, Maureen
dc.contributor.author
Kleensang, Andre
dc.contributor.author
Lewis, Matthew R.
dc.contributor.author
Monge, Maria Eugenia
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Mosley, Jonathan D.
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Taylor, Eric
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Tayyari, Fariba
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Theodoridis, Georgios
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Torta, Federico
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Ubhi, Baljit K.
dc.contributor.author
Vuckovic, Dajana
dc.date.available
2021-08-20T13:36:35Z
dc.date.issued
2020-10
dc.identifier.citation
Evans, Anne M.; ODonovan, Claire; Playdon, Mary; Beecher, Chris; Beger, Richard D.; et al.; Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC–MS based untargeted metabolomics practitioners; Springer; Metabolomics; 16; 10; 10-2020; 1-16
dc.identifier.issn
1573-3882
dc.identifier.uri
http://hdl.handle.net/11336/138616
dc.description.abstract
Introduction: The metabolomics quality assurance and quality control consortium (mQACC) evolved from the recognized need for a community-wide consensus on improving and systematizing quality assurance (QA) and quality control (QC) practices for untargeted metabolomics. Objectives: In this work, we sought to identify and share the common and divergent QA and QC practices amongst mQACC members and collaborators who use liquid chromatography-mass spectrometry (LC–MS) in untargeted metabolomics. Methods: All authors voluntarily participated in this collaborative research project by providing the details of and insights into the QA and QC practices used in their laboratories. This sharing was enabled via a six-page questionnaire composed of over 120 questions and comment fields which was developed as part of this work and has proved the basis for ongoing mQACC outreach. Results: For QA, many laboratories reported documenting maintenance, calibration and tuning (82%); having established data storage and archival processes (71%); depositing data in public repositories (55%); having standard operating procedures (SOPs) in place for all laboratory processes (68%) and training staff on laboratory processes (55%). For QC, universal practices included using system suitability procedures (100%) and using a robust system of identification (Metabolomics Standards Initiative level 1 identification standards) for at least some of the detected compounds. Most laboratories used QC samples (>86%); used internal standards (91%); used a designated analytical acquisition template with randomized experimental samples (91%); and manually reviewed peak integration following data acquisition (86%). A minority of laboratories included technical replicates of experimental samples in their workflows (36%). Conclusions: Although the 23 contributors were researchers with diverse and international backgrounds from academia, industry and government, they are not necessarily representative of the worldwide pool of practitioners due to the recruitment method for participants and its voluntary nature. However, both questionnaire and the findings presented here have already informed and led other data gathering efforts by mQACC at conferences and other outreach activities and will continue to evolve in order to guide discussions for recommendations of best practices within the community and to establish internationally agreed upon reporting standards. We very much welcome further feedback from readers of this article.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
LC-MS
dc.subject
METABOLOMICS QUALITY ASSURANCE AND QUALITY CONTROL CONSORTIUM (MQACC)
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QUALITY ASSURANCE
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QUALITY CONTROL
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UNTARGETED METABOLOMICS
dc.subject.classification
Química Analítica
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Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC–MS based untargeted metabolomics practitioners
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-12-04T19:55:13Z
dc.journal.volume
16
dc.journal.number
10
dc.journal.pagination
1-16
dc.journal.pais
Alemania
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dc.description.fil
Fil: Evans, Anne M.. No especifíca;
dc.description.fil
Fil: ODonovan, Claire. European Bioinformatics Institute; Reino Unido
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Fil: Playdon, Mary. University of Utah; Estados Unidos
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Fil: Beecher, Chris. No especifíca;
dc.description.fil
Fil: Beger, Richard D.. National Center For Toxicological Research; Estados Unidos
dc.description.fil
Fil: Bowden, John A.. University of Florida; Estados Unidos
dc.description.fil
Fil: Broadhurst, David. Edith Cowan University; Australia
dc.description.fil
Fil: Clish, Clary B.. Broad Institute; Estados Unidos
dc.description.fil
Fil: Dasari, Surendra. Mayo Clinic; Estados Unidos
dc.description.fil
Fil: Dunn, Warwick B.. University Of Birmingham; Reino Unido
dc.description.fil
Fil: Griffin, Julian L.. University of Cambridge; Estados Unidos. Imperial College London; Reino Unido
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Fil: Hartung, Thomas. University Johns Hopkins; Estados Unidos
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Fil: Hsu, Ping Ching. University of Arkansas for Medical Sciences; Estados Unidos
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Fil: Huan, Tao. University of British Columbia; Canadá
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Fil: Jans, Judith. University of Utrecht; Países Bajos
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Fil: Jones, Christina M.. National Institute Of Standards And Technology; Estados Unidos
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Fil: Kachman, Maureen. Michigan State University; Estados Unidos
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Fil: Kleensang, Andre. University Johns Hopkins; Estados Unidos
dc.description.fil
Fil: Lewis, Matthew R.. Imperial College London; Reino Unido
dc.description.fil
Fil: Monge, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Bionanociencias "Elizabeth Jares Erijman"; Argentina
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Fil: Mosley, Jonathan D.. Environmental Protection Agency; Estados Unidos
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Fil: Taylor, Eric. University of Iowa; Estados Unidos
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Fil: Tayyari, Fariba. University of Iowa; Estados Unidos
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Fil: Theodoridis, Georgios. Aristotle University; Grecia
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Fil: Torta, Federico. No especifíca;
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Fil: Ubhi, Baljit K.. No especifíca;
dc.description.fil
Fil: Vuckovic, Dajana. Concordia University; Canadá
dc.journal.title
Metabolomics
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11306-020-01728-5
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11306-020-01728-5
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