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dc.contributor.author
Ortega, Francisco G.
dc.contributor.author
Regiart, Matías D.
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Rodríguez Martínez, Alba
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De Miguel-Pérez, Diego
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Serrano, María J.
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Lorente, José A.
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Tortella, Gonzalo
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Rubilar, Olga
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Sapag, Manuel Karim
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Bertotti, Mauro
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Fernández Baldo, Martín Alejandro
dc.date.available
2021-08-19T12:45:07Z
dc.date.issued
2020-12
dc.identifier.citation
Ortega, Francisco G.; Regiart, Matías D.; Rodríguez Martínez, Alba; De Miguel-Pérez, Diego; Serrano, María J.; et al.; Sandwich-Type Electrochemical Paper-Based Immunosensor for Claudin 7 and CD81 Dual Determination on Extracellular Vesicles from Breast Cancer Patients; American Chemical Society; Analytical Chemistry; 93; 2; 12-2020; 1143-1153
dc.identifier.issn
0003-2700
dc.identifier.uri
http://hdl.handle.net/11336/138506
dc.description.abstract
This study is focused on identifying novel epithelial markers in circulating extracellular vesicles (EVs) through the development of a dual sandwich-type electrochemical paper-based immunosensor for Claudin 7 and CD81 determination, as well as its validation in breast cancer (BC) patients. This immunosensor allows for rapid, sensitive, and label-free detection of these two relevant BC biomarkers. Under optimum conditions, the limit of detection for Claudin 7 was 0.4 pg mL-1, with a wide linear range of 2 to 1000 pg mL-1, while for CD81, the limit of detection was 3 pg mL-1, with a wide linear range of 0.01 to 10 ng mL-1. Finally, we validated Claudin 7 and CD81 determination in EVs from 60 BC patients and 20 healthy volunteers, reporting higher diagnostic accuracy than the one observed with classical diagnostic markers. This analysis provides a low-cost, specific, versatile, and user-friendly strategy as a robust and reliable tool for early BC diagnosis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CLAUDIN 7
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CD81
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BIOMARKERS
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BREAST CANCER
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CANCER DIAGNOSIS
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EXTRACELLULAR VESICLES
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PAPER IMMUNOSENSOR
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ELECTROCHEMICAL
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Química Analítica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Sandwich-Type Electrochemical Paper-Based Immunosensor for Claudin 7 and CD81 Dual Determination on Extracellular Vesicles from Breast Cancer Patients
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-01-27T19:50:59Z
dc.journal.volume
93
dc.journal.number
2
dc.journal.pagination
1143-1153
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Ortega, Francisco G.. Balearic Islands Health Research Institute; España
dc.description.fil
Fil: Regiart, Matías D.. Universidade de Sao Paulo; Brasil
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Fil: Rodríguez Martínez, Alba. Universidad de Granada; España
dc.description.fil
Fil: De Miguel-Pérez, Diego. Universidad de Granada; España
dc.description.fil
Fil: Serrano, María J.. Universidad de Granada; España
dc.description.fil
Fil: Lorente, José A.. Universidad de Granada; España
dc.description.fil
Fil: Tortella, Gonzalo. Universidad de La Frontera; Chile
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Fil: Rubilar, Olga. Universidad de La Frontera; Chile
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Fil: Sapag, Manuel Karim. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina
dc.description.fil
Fil: Bertotti, Mauro. Universidade de Sao Paulo; Brasil
dc.description.fil
Fil: Fernández Baldo, Martín Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
dc.journal.title
Analytical Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.acs.org/doi/10.1021/acs.analchem.0c04180
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/acs.analchem.0c04180
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