Natriuretic Peptide Receptor Type C

Abstract

NPRC has traditionally been considered a clearance receptor of NPs responsible for receptor-mediated degradation of these peptides. In the last years, this view has been overcome by several studies showing evidence of NPRC multiple effects on different cells and organs and of the existence of a specific intracellular mechanism of action. These effects would be mediated by CNP stimulation rather than by ANP and BNP. A main role on vascular, cardiac and metabolic physiology and on bone turnover has been proposed. Many studies indicate that alterations of NPRC function and structure as well as the existence of gene polymorphisms would be implicated in the pathophysiology of several diseases. Further investigation is needed to completely elucidate the physiological role played by NPRC and also to understand how NPRC alterations at gene and protein level could contribute to the development of pathological states as a cause of natriuretic system disruption.