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dc.contributor.author
Bustos, Daniela Alicia
dc.contributor.author
Salem, Romina
dc.contributor.author
Varela, Patricia
dc.contributor.author
Pacciaroni, Adriana del Valle
dc.contributor.author
Sosa, Virginia Estela
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dc.contributor.author
Bustos, Daniel Alfredo
dc.date.available
2017-03-14T16:05:06Z
dc.date.issued
2014-01
dc.identifier.citation
Bustos, Daniela Alicia; Salem, Romina; Varela, Patricia; Pacciaroni, Adriana del Valle; Sosa, Virginia Estela; et al.; Bioreduction of (-)-achalensolide using pure strains of penicillium sp. and rhizopus sp.; Trade Science inc; Organic Chemistry and Indian Journal; 10; 4; 1-2014; 140-144
dc.identifier.issn
0974-7516
dc.identifier.uri
http://hdl.handle.net/11336/13834
dc.description.abstract
Natural products and related structures are an important source of compoundswith biological activity. Biotransformations of organicmolecules provides the ability to obtain new compounds which can be tested. This technique has the advantage of enabling functionalized organic compounds using enzymes in microorganisms through simple reactions, in a regio-and stereoselective way, in mild conditions and avoiding polluting the environment. In order to look for new active compounds, pure strains of phytopatogenic fungi Penicillium sp. and Rhizopus sp., were used to transform the sesquiterpene lactone (-)-achalensolide in a regio and streoselective way to obtain one reduced metabolite, 11â,13- dihydroachalensolide. A two stages standard protocol was used and after isolation and purification of product, IR, 1H and 13C NMR spectroscopy allowed to confirmits structure. 1,1-diphenyl-2-picrylhydrazyl and Artemia salina in vitro assays were done to test starting material and product obtained. They showed weak similar activity when compared to reference compounds, so structural modification had no effect on it.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Trade Science inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Biotransformation
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Achalensolide
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Reduction
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Fungi
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Química Orgánica
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Bioreduction of (-)-achalensolide using pure strains of penicillium sp. and rhizopus sp.
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-01T18:05:25Z
dc.journal.volume
10
dc.journal.number
4
dc.journal.pagination
140-144
dc.journal.pais
India
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dc.journal.ciudad
Gujarat
dc.description.fil
Fil: Bustos, Daniela Alicia. Universidad Nacional de San Juan. Facultad de Filosofia, Humanidades y Artes. Instituto de Cs.basicas. Area de Quimica; Argentina
dc.description.fil
Fil: Salem, Romina. Universidad Nacional de San Juan. Facultad de Filosofia, Humanidades y Artes. Instituto de Cs.basicas. Area de Quimica; Argentina
dc.description.fil
Fil: Varela, Patricia. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
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Fil: Pacciaroni, Adriana del Valle. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
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Fil: Sosa, Virginia Estela. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Química Orgánica; Argentina
dc.description.fil
Fil: Bustos, Daniel Alfredo. Universidad Nacional de San Juan. Facultad de Filosofia, Humanidades y Artes. Instituto de Cs.basicas. Area de Quimica; Argentina
dc.journal.title
Organic Chemistry and Indian Journal
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.tsijournals.com/abstract/synthesis-for-the-4-4arylmethylenebis1hpyrazol5ols-in-aqueous-mediumundermicrowave-irradiation-in-presence-of-ionic-surf-5064.html
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