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dc.contributor.author
Fainboim, Leonardo
dc.contributor.author
Belén, Santiago
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Gonzalez, Veronica Andrea
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Fernandez, Pablo Mariano
dc.date.available
2021-08-12T16:01:57Z
dc.date.issued
2021-08
dc.identifier.citation
Fainboim, Leonardo; Belén, Santiago; Gonzalez, Veronica Andrea; Fernandez, Pablo Mariano; Evaluation of paternal lymphocyte immunotherapy and potential biomarker mixed lymphocyte reaction-blocking factor in an Argentinian cohort of women with unexplained recurrent spontaneous abortion and unexplained infertility; Wiley Blackwell Publishing, Inc; American Journal of Reproductive Immunology; 86; 2; 8-2021; 1-10
dc.identifier.issn
1046-7408
dc.identifier.uri
http://hdl.handle.net/11336/138207
dc.description.abstract
Problem: Analyze the effect of paternal immunotherapy treatment (PIT) in primary and secondary unexplained recurrent spontaneous abortion (URSA) and unexplained infertility (UI). Methods of Study: A retrospective study analyzed a two-year follow-up between the generation of MLR-Bfs after PIT treatment (or controls first consultation) and a live birth. Recruited patients included primary URSA with two or more miscarriages at <12 weeks gestation, secondary URSA with previous live birth before two or more miscarriages, and UI with inability to conceive after 2 years of regular unprotected intercourse or in vitro fertilizations (IVF). PIT treated were compared with untreated controls. Results: Primary URSA: live birth was 241/416 (58%) versus 64/282 (23%) controls (p <.0001). Up to age 35, success was 158/217 (73%) and 37/144 (26%) controls (p <.0001). With 3 or more previous URSA, success was 90/135 (67%) versus 17/79 (22%) controls (p <.0001). Between ages 36 and 40, success was 69/147(47%) versus 22/98 (22%) controls (p <.0003), with 3 or more previous URSA live birth was 45/95 (47%) versus 6/46 (13%) controls (p <.0001). In UI, live birth was 99/298 (33%) versus 54/263 (21%) in controls (p <.0009) that increased under age 35 to 53/116 (46%) in treated versus 26/101 (26%) controls (p <.0056). In PIT treated, IVF success required a median of 1 (1.37 ± 0.67) versus a median of 3 IVF procedures (2.75 ± 0.84) in controls. Conclusion: PIT is a successful treatment for primary and secondary URSA, and UI. PIT reduced the number of IVF required for achieving pregnancy.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
FERTILIZATION IN VITRO
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IVF FAILURES
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PATERNAL IMMUNOTHERAPY
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PRIMARY URSA
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REPRODUCTIVE OUTCOME
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SECONDARY URSA
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UNEXPLAINED INFERTILITY
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Otras Ciencias de la Salud
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Evaluation of paternal lymphocyte immunotherapy and potential biomarker mixed lymphocyte reaction-blocking factor in an Argentinian cohort of women with unexplained recurrent spontaneous abortion and unexplained infertility
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-07-01T14:24:47Z
dc.journal.volume
86
dc.journal.number
2
dc.journal.pagination
1-10
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Fainboim, Leonardo. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.description.fil
Fil: Belén, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.description.fil
Fil: Gonzalez, Veronica Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina
dc.description.fil
Fil: Fernandez, Pablo Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
dc.journal.title
American Journal of Reproductive Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/aji.13422
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1111/aji.13422
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