Artículo
Perforin and granzymes in neurological infections: From humans to cattle
Fecha de publicación:
04/2021
Editorial:
Elsevier
Revista:
Comparative Immunology, Microbiology and Infectious Diseases
ISSN:
0147-9571
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Perforin and granzymes are essential components of the cytotoxic granules present in cytotoxic T lymphocytes and natural killer cells. These proteins play a crucial role in a variety of conditions, including viral infections, tumor immune surveillance, and tissue rejection. Besides their beneficial effect in most of these situations, perforin and granzymes have also been associated with tissue damage and immune diseases. Moreover, it has been reported that perforin and granzymes released during viral infections could contribute to the pathogenesis of diseases. In this review, we summarize the information available on human perforin and granzymes and their relationship with neurological infections and immune disorders. Furthermore, we compare this information with that available for bovine and present data on perforin and granzymes expression in cattle infected with bovine alphaherpesvirus types1 and -5. To our knowledge, this is the first review analyzing the impact of perforin and granzymes on neurological infections caused by bovine herpesviruses.
Palabras clave:
ALPHAHERPESVIRUS
,
CATTLE
,
GRANZYME
,
NEUROPATHOLOGY
,
PERFORIN
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CIVETAN)
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Articulos de CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Citación
Martinez Cuesta, Lucia; Perez, Sandra; Perforin and granzymes in neurological infections: From humans to cattle; Elsevier; Comparative Immunology, Microbiology and Infectious Diseases; 75; 4-2021; 1-8
Compartir
Altmétricas