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dc.contributor.author
Baldessari, Alicia
dc.contributor.author
Garcia Liñares, Guadalupe Eugenia
dc.contributor.other
Sandoval, Georgina
dc.date.available
2021-08-10T12:45:26Z
dc.date.issued
2018
dc.identifier.citation
Baldessari, Alicia; Garcia Liñares, Guadalupe Eugenia; Lipase-Catalyzed Acetylation and Esterification of Bile Acids; Humana Press; 2018; 100-130
dc.identifier.isbn
978-1-61779-600-5
dc.identifier.uri
http://hdl.handle.net/11336/138067
dc.description.abstract
In this chapter we describe the application of lipases as catalysts in reactions on a relevant family of steroids: the bile acids. Twenty three mono-, diacetyl and ester derivatives of deoxycholic-, chenodeoxycholic-, lithocholic- and cholic acid, fifteen of them new compounds, were obtained through lipase-catalyzed acetylation, esterification and alcoholysis reactions in very good to excellent yield and a highly regioselective way. Among them, acetylated ester products, in which the lipase catalyzed both reactions in one-pot, were obtained. The influence of various reaction parameters in the enzymatic reactions, such as enzyme source, nucleophile/substrate ratio, enzyme/substrate ratio, solvent and temperature, was studied. Some of the reported products are novel and it is not possible to obtain them satisfactorily by following traditional synthetic procedures. Due to its singular structure containing three hydroxyl groups, cholic acid showed a different behavior in the enzymatic reactions, from that observed for the other three bile acids studied. In order to shed light to different behavior of bile acids in the enzymatic reactions, molecular modeling was applied to substrates and some derivatives.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Humana Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Lipases
dc.subject
Acetylation
dc.subject
Esterification
dc.subject
Bile acids
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Otras Ciencias Químicas
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Lipase-Catalyzed Acetylation and Esterification of Bile Acids
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2021-04-30T20:14:52Z
dc.journal.pagination
100-130
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Baldessari, Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
dc.description.fil
Fil: Garcia Liñares, Guadalupe Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.springer.com/gp/book/9781493986712
dc.conicet.paginas
500
dc.source.titulo
Lipases and Phospholipases: methods and protocols
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