Artículo
Progesterone modulates the LPS-induced nitric oxide production by a progesterone-receptor independent mechanism
Wolfson, Manuel Luis
; Schander, Julieta Aylen
; Bariani, Maria Victoria
; Correa, Fernando Gabriel
; Franchi, Ana Maria
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Fecha de publicación:
12/2015
Editorial:
Elsevier Science
Revista:
European Journal of Pharmacology
ISSN:
0014-2999
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Genital tract infections caused by Gram-negative bacteria induce miscarriage and are one of the most common complications of human pregnancy. LPS administration to 7-day pregnant mice induces embryo resorption after 24h, with nitric oxide playing a fundamental role in this process. We have previously shown that progesterone exerts protective effects on the embryo by modulating the inflammatory reaction triggered by LPS. Here we sought to investigate whether the in vivo administration of progesterone modulated the LPS-induced nitric oxide production from peripheral blood mononuclear cells from pregnant and non-pregnant mice. We found that progesterone downregulated LPS-induced nitric oxide production by a progesterone receptor-independent mechanism. Moreover, our results suggest a possible participation of glucocorticoid receptors in at least some of the anti-inflammatory effects of progesterone.
Palabras clave:
Progesterone
,
Nitric Oxide
,
Glucocorticoid Receptors
,
Ru486
,
Lonaprisan
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(CEFYBO)
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Articulos de CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Citación
Wolfson, Manuel Luis; Schander, Julieta Aylen; Bariani, Maria Victoria; Correa, Fernando Gabriel; Franchi, Ana Maria; Progesterone modulates the LPS-induced nitric oxide production by a progesterone-receptor independent mechanism; Elsevier Science; European Journal of Pharmacology; 769; 12-2015; 110-116
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