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dc.contributor.author
Salerno, Aurelio
dc.contributor.author
Leonardi, Agustina Belen
dc.contributor.author
Pedram, Parisa
dc.contributor.author
Di Maio, Ernesto
dc.contributor.author
Fanovich, Maria Alejandra
dc.contributor.author
Netti, Paolo A.
dc.date.available
2021-08-02T18:35:22Z
dc.date.issued
2020-04
dc.identifier.citation
Salerno, Aurelio; Leonardi, Agustina Belen; Pedram, Parisa; Di Maio, Ernesto; Fanovich, Maria Alejandra; et al.; Tuning the three-dimensional architecture of supercritical CO2 foamed PCL scaffolds by a novel mould patterning approach; Elsevier Science; Materials Science and Engineering: C; 109; 4-2020; 1-16
dc.identifier.issn
0928-4931
dc.identifier.uri
http://hdl.handle.net/11336/137597
dc.description.abstract
In tissue engineering, the use of supercritical CO2 foaming is a valuable and widespread choice to design and fabricate porous bioactive scaffolds for cells culture and new tissue formation in three dimensions. Nevertheless, the control of scaffold pores size, shape and spatial distribution with foaming technique remains, to date, a critical limiting step. To mimic the biomimetic structure of tissues like bone, blood vessels and nerve tissues, we developed a novel supercritical CO2-foaming approach for the preparation of dual-scale, dual-shape porous polymeric scaffolds with pre-defined arrays of micro-channels within a foamed porosity. The scaffolds were prepared by foaming the polymer inside polytetrafluoroethylene moulds having precisely designed arrays of pillars and obtained by computer-aided micromachining technique. Polycaprolactone was chosen as model polymer for scaffolds fabrication and the effect of mould patterning and scCO2 foaming conditions on scaffolds morphology, structural properties and biocompatibility was addressed and discussed. The results reported in this study demonstrated that the proposed approach enabled the preparation of polycaprolactone scaffolds with dual-scale, dual-shape porosity. In particular, by saturating the polymer with CO2 at 38 °C, 10 MPa and 1 h and by selecting 2 s as the venting time, scaffolds with ordered arrays of aligned channels, diameters ranging from 500 to 1000 μm, were obtained. Furthermore, the channels spatial distribution was controlled by defining mould patterning while the size of foamed pores was modulated by saturation and foaming temperatures and venting time control. The prepared scaffolds evidenced overall porosity up to 95%, with 100% interconnectivity and compression moduli in the 4 to 5 MPa range. Finally, preliminary in vitro cell culture tests evidenced that the scaffolds were biocompatible and that the micro-channels promoted and guided cells adhesion and colonization into the scaffolds core.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ALIGNED CHANNELS
dc.subject
POLYCAPROLACTONE
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POROUS SCAFFOLDS
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SUPERCRITICAL CO2 FOAMING
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Otras Ingeniería de los Materiales
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Ingeniería de los Materiales
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Tuning the three-dimensional architecture of supercritical CO2 foamed PCL scaffolds by a novel mould patterning approach
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-06-07T15:29:56Z
dc.journal.volume
109
dc.journal.pagination
1-16
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Salerno, Aurelio. Istituto Italiano Di Tecnologia; Italia
dc.description.fil
Fil: Leonardi, Agustina Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.description.fil
Fil: Pedram, Parisa. Università degli Studi di Napoli Federico II; Italia
dc.description.fil
Fil: Di Maio, Ernesto. Università degli Studi di Napoli Federico II; Italia
dc.description.fil
Fil: Fanovich, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
dc.description.fil
Fil: Netti, Paolo A.. Istituto Italiano Di Tecnologia; Italia. Università degli Studi di Napoli Federico II; Italia
dc.journal.title
Materials Science and Engineering: C
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.msec.2019.110518
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0928493119323136
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