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dc.contributor.author
Machuca, Laura Marcela
dc.contributor.author
Murguia, Marcelo Cesar
dc.contributor.other
Adnan, Suraya Hani
dc.date.available
2021-07-31T20:07:10Z
dc.date.issued
2020
dc.identifier.citation
Machuca, Laura Marcela; Murguia, Marcelo Cesar; Design, Synthesis and Insecticidal Activities of Novel Pirazol Derivatives to Crop Protection; SCIENCEDOMAIN International; 9; 2020; 95-107
dc.identifier.isbn
978-93-90206-36-0
dc.identifier.uri
http://hdl.handle.net/11336/137537
dc.description.abstract
Aryl pyrazoles are compounds that display very interesting biological activities. This chapter reviews recent work of our group in the development of synthetic strategies for the preparation of new examples of these kinds of compounds to crop protection. A series of six N-aryl pyrazoles was synthesized by Michael-type addition reaction. The molecules 5-amino-1-aryl-1H-pyrazole-4-carbonitrile (3a-f) were synthesized from (ethoxymethylene)malononitrile (1) and fluorinated and non-fluorinated aryl hydrazines (2a-f) using ethanol and fluorinated ethanol as solvents at reflux. An excellent regio-selectivity was found when pyrazole de- rivatives were formed as an exclusive product. No other regioisomer or uncyclised hydrazide was observed. Their structures were confirmed by spectroscopy data (1H, 13C, 19F, COSY (correlation spectroscopy), HSQC (heteronuclear single-quantum correlation spectroscopy) and HMBC (heteronuclear multiple-bond correlation spectroscopy); MS (mass-spectrometry). The yields ranged from good to excellent (47% - 93%) under mild reaction conditions. It would indicate a high selectivity in the one-step work procedure. These products (3a-f) and derivatives have a potential academic and industrial use as key intermediates, in special for application in crop protection.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
SCIENCEDOMAIN International
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
N-ARYL PIRAZOLE
dc.subject
ARYL HYDRAZINE
dc.subject
TUTA ABSOLUTA
dc.subject
5-AMINO-1-ARYL-1H-PYRAZOLE-4-CARBONITRILES
dc.subject.classification
Química Orgánica
dc.subject.classification
Ciencias Químicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Design, Synthesis and Insecticidal Activities of Novel Pirazol Derivatives to Crop Protection
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2021-07-30T19:18:09Z
dc.journal.volume
9
dc.journal.pagination
95-107
dc.journal.pais
India
dc.description.fil
Fil: Machuca, Laura Marcela. Universidad Nacional del Litoral; Argentina
dc.description.fil
Fil: Murguia, Marcelo Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.9734/bpi/etert/v9
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://bp.bookpi.org/index.php/bpi/catalog/book/235
dc.conicet.paginas
400
dc.source.titulo
Emerging Trends in Engineering Research and Technology
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