Artículo
Reprogramming the tumor metastasis cascade by targeting galectin-driven networks
Fecha de publicación:
02/2021
Editorial:
Portland Press
Revista:
Biochemical Journal
ISSN:
0264-6021
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
A sequence of interconnected events known as the metastatic cascade promotes tumor progression by regulating cellular and molecular interactions between tumor, stromal, endothelial, and immune cells both locally and systemically. Recently, a new concept has emerged to better describe this process by defining four attributes that metastatic cells should undergo. Every individual hallmark represents a unique trait of a metastatic cell that impacts directly in the outcome of the metastasis process. These critical features, known as the hallmarks of metastasis, include motility and invasion, modulation of the microenvironment, cell plasticity and colonization. They are hierarchically regulated at different levels by several factors, including galectins, a highly conserved family of β-galactoside-binding proteins abundantly expressed in tumor microenvironments and sites of metastasis. In this review, we discuss the role of galectins in modulating each hallmark of metastasis, highlighting novel therapeutic opportunities for treating the metastatic disease.
Palabras clave:
METASTASIS
,
CASCADA
,
GALECTINAS
,
CANCER
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Perrotta, Ramiro Martin; Bach, Camila Agustina; Salatino, Mariana; Rabinovich, Gabriel Adrián; Reprogramming the tumor metastasis cascade by targeting galectin-driven networks; Portland Press; Biochemical Journal; 478; 3; 2-2021; 597-617
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