Mostrar el registro sencillo del ítem
dc.contributor.author
Monsalve Bravo, Gloria Milena
dc.contributor.author
Garelli, Fabricio
dc.contributor.author
Mozumder, Salatul Islam
dc.contributor.author
Alvarez, Hernán
dc.contributor.author
de Battista, Hernan
dc.date.available
2017-03-10T20:57:44Z
dc.date.issued
2015-06
dc.identifier.citation
Monsalve Bravo, Gloria Milena; Garelli, Fabricio; Mozumder, Salatul Islam; Alvarez, Hernán; de Battista, Hernan; Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production; Springer Verlag Berlín; Bioprocess And Biosystems Engineering; 38; 6; 6-2015; 1179-1190
dc.identifier.issn
1615-7591
dc.identifier.uri
http://hdl.handle.net/11336/13736
dc.description.abstract
This work presents a general model-based methodology to scale-up fed-batch bioprocesses. The idea behind this approach is to establish a dynamics hierarchy, based on a model of the process, that allows the designer to determine the proper scale factors as well as at which point of the fed-batch the process should be scaled up. Here, concepts and tools of linear control theory, such as the singular value decomposition of the Hankel matrix, are exploited in the context of process design. The proposed scale-up methodology is first described in a bioprocesses general framework highlighting its main features, key variables and parameters. Then, it is applied to a polyhydroxybutyrate (PHB) fed-batch bioreactor and compared with three empirical criteria, that are traditionally employed to determine the scale factors of these processes, showing the usefulness and distinctive features of this proposal. Moreover, this methodology provides theoretical support to a frequently used empirical rule: scale-up aerobic bioreactors at constant volumetric oxygen transfer coefficient. Finally, similar process dynamic behavior and PHB production set at the laboratory scale are predicted at the new operating scale, while it is also determined that is rarely possible to reproduce similar dynamic behavior of the bioreactor using empirical scale-up criteria.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer Verlag Berlín
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Scale Up
dc.subject
Bioprocess
dc.subject
Hankel Matrix
dc.subject
Dynamics Hierarchy
dc.subject.classification
Sistemas de Automatización y Control
dc.subject.classification
Ingeniería Eléctrica, Ingeniería Electrónica e Ingeniería de la Información
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Model-based scale-up methodology for aerobic fed-batch bioprocesses: application to polyhydroxybutyrate (PHB) production
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-08T15:39:36Z
dc.identifier.eissn
1615-7605
dc.journal.volume
38
dc.journal.number
6
dc.journal.pagination
1179-1190
dc.journal.pais
Alemania
dc.journal.ciudad
Berlin
dc.description.fil
Fil: Monsalve Bravo, Gloria Milena. Universidad Nacional de Colombia; Colombia. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina
dc.description.fil
Fil: Garelli, Fabricio. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Mozumder, Salatul Islam. University of Ghent; Bélgica. Flemish Institute for Technological Research; Bélgica
dc.description.fil
Fil: Alvarez, Hernán. Universidad Nacional de Colombia; Colombia
dc.description.fil
Fil: de Battista, Hernan. Universidad Nacional de la Plata. Facultad de Ingenieria. Departamento de Electrotecnia. Laboratorio de Electronica Ind., Control E Instrumentac.; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Bioprocess And Biosystems Engineering
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00449-015-1360-4
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00449-015-1360-4
Archivos asociados