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dc.contributor.author
Caldart Valle, Carlos Sebastian
dc.contributor.author
Carpaneto Freixas, Agustín Eduardo
dc.contributor.author
Golombek, Diego Andrés
dc.date.available
2021-07-29T18:57:05Z
dc.date.issued
2020-10
dc.identifier.citation
Caldart Valle, Carlos Sebastian; Carpaneto Freixas, Agustín Eduardo; Golombek, Diego Andrés; Synchronization of circadian locomotor activity behavior in Caernorhabditis elegans: Interactions between light and temperature; Elsevier Science SA; Journal of Photochemistry and Photobiology B: Biology; 211; 112000; 10-2020; 1-7
dc.identifier.issn
1011-1344
dc.identifier.uri
http://hdl.handle.net/11336/137369
dc.description.abstract
Circadian rhythms are driven by an endogenous clock which is synchronized by daily environmental cycles (known as zeitgebers). Although the circadian responses of C. elegans to light have been recently reported, the mechanisms and pathways involved in their synchronization are still unknown. Here we present, by means of a novel behavioral approach, a complete characterization of C. elegans circadian synchronization to light and temperature cycles. Moreover, we screened mutant strains in search of defects of photic and thermal responses in order to study their putative pathways. We show that the wild-type strain is able to synchronize to combined cycles of light and temperature, with the best performance achieved under an optimal combination and phase-relationship of zeitgebers (high temperature in the dark phase and low temperature in the light phase). A lower responsiveness for the mutant strains MT21793 (lite-1/gur3 ko) and IK597 (gcy 8, 18 and 23 ko) was found in response to light and temperature, respectively. However, both mutants were still able to synchronize to a combined cycle of both stimuli. Our results shed light on the response of C. elegans to different zeitgebers as well as their possible synchronization pathways, the molecular components involved in these pathways, and their relative strength.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science SA
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
C. ELEGANS
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CIRCADIAN ENTRAINMENT
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PHOTIC SYNCHRONIZATION
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THERMIC SYNCHRONIZATION - LITE PATHWAY
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Synchronization of circadian locomotor activity behavior in Caernorhabditis elegans: Interactions between light and temperature
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-07-29T11:42:45Z
dc.journal.volume
211
dc.journal.number
112000
dc.journal.pagination
1-7
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Caldart Valle, Carlos Sebastian. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Carpaneto Freixas, Agustín Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
dc.description.fil
Fil: Golombek, Diego Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
dc.journal.title
Journal of Photochemistry and Photobiology B: Biology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jphotobiol.2020.112000
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1011134420304504
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