Artículo
Neuroprotective effect of melatonin loaded in ethylcellulose nanoparticles applied topically in a retinal degeneration model in rabbits
Bessone, Carolina del Valle
; Martinez, Sofía Inés
; Luna, José Domingo; Márquez, Marilyn A.; Ramirez, Maria Laura
; Allemandi, Daniel Alberto
; Carpentieri, Agata Rita
; Quinteros, Daniela Alejandra
Fecha de publicación:
11/2020
Editorial:
Academic Press Ltd - Elsevier Science Ltd
Revista:
Experimental Eye Research
ISSN:
0014-4835
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
We are reporting for the first time the synthesis and application of an innovative nanometric system for the controlled topic release of melatonin in the retina. The ethylcellulose nanocapsules were characterized by diverse physicochemical techniques (scanning electron microscopy, zeta potential, hydrodynamic diameters) and an in vitro release study was done. A complete ex vivo and in vivo trans-corneal permeation and an irritation study were carried out with the new formulations in albino rabbits, to which a retinal degenerative model was induced. The results obtained demonstrate that the in vitro release of melatonin (1 mg/mL and 2 mg/mL) transported by nanocapsules is slower when compared to a solution of melatonin. Greater penetration of melatonin through the cornea was demonstrated by ex vivo and in vivo tests. This can be attributable to an enhanced neuroprotective effect of melatonin on retinal ganglion cells when it is included in ethylcellulose nanocapsules compared to a solution of melatonin. These outstanding findings add promising new perspectives to current knowledge about administrations using nano-technological tools in the treatment of neurodegenerative diseases at the ocular level.
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Articulos(UNITEFA)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Citación
Bessone, Carolina del Valle; Martinez, Sofía Inés; Luna, José Domingo; Márquez, Marilyn A.; Ramirez, Maria Laura; et al.; Neuroprotective effect of melatonin loaded in ethylcellulose nanoparticles applied topically in a retinal degeneration model in rabbits; Academic Press Ltd - Elsevier Science Ltd; Experimental Eye Research; 200; 11-2020; 1-35
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