Mostrar el registro sencillo del ítem
dc.contributor.author
Timotius, Ivanna K.
dc.contributor.author
Bieler, Lara
dc.contributor.author
Couillard Despres, Sebastien
dc.contributor.author
Sandner, Beatrice
dc.contributor.author
Garcia Ovejero, Daniel
dc.contributor.author
Labombarda, Maria Florencia
dc.contributor.author
Estrada, Veronica
dc.contributor.author
Müller, Hans W.
dc.contributor.author
Winkler, Jürgen
dc.contributor.author
Klucken, Jochen
dc.contributor.author
Eskofier, Bjoern
dc.contributor.author
Weidner, Norbert
dc.contributor.author
Puttagunta, Radhika
dc.date.available
2021-07-28T20:11:42Z
dc.date.issued
2021-03
dc.identifier.citation
Timotius, Ivanna K.; Bieler, Lara; Couillard Despres, Sebastien; Sandner, Beatrice; Garcia Ovejero, Daniel; et al.; Combination of defined catwalk gait parameters for predictive locomotion recovery in experimental spinal cord injury rat models; Society for Neuroscience; eNeuro; 8; 2; 3-2021; 1-14
dc.identifier.issn
2373-2822
dc.identifier.uri
http://hdl.handle.net/11336/137291
dc.description.abstract
In many preclinical spinal cord injury (SCI) studies, assessment of locomotion recovery is key to understanding the effectiveness of the experimental intervention. In such rat SCI studies, the most basic locomotor recovery scoring system is a subjective observation of animals freely roaming in an open field, the Basso Beattie Bresnahan (BBB) score. In comparison, CatWalk is an automated gait analysis system, providing further parameter specifications. Although together the CatWalk parameters encompass gait, studies consistently report single parameters, which differ in significance from other behavioral assessments. Therefore, we believe no single parameter produced by the CatWalk can represent the fully-coordinated motion of gait. Typically, other locomotor assessments, such as the BBB score, combine several locomotor characteristics into a representative score. For this reason, we ranked the most distinctive CatWalk parameters between uninjured and SC injured rats. Subsequently, we combined nine of the topmost parameters into an SCI gait index score based on linear discriminant analysis (LDA). The resulting combination was applied to assess gait recovery in SCI experiments comprising of three thoracic contusions, a thoracic dorsal hemisection, and a cervical dorsal column lesion model. For thoracic lesions, our unbiased machine learning model revealed gait differences in lesion type and severity. In some instances, our LDA was found to be more sensitive in differentiating recovery than the BBB score alone. We believe the newly developed gait parameter combination presented here should be used in CatWalk gait recovery work with preclinical thoracic rat SCI models.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for Neuroscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
CATWALK
dc.subject
GAIT PARAMETER
dc.subject
LINEAR DISCRIMINANT ANALYSIS
dc.subject
LOCOMOTION RECOVERY
dc.subject
PRECLINICAL DEVELOPMENT
dc.subject
SPINAL CORD INJURY
dc.subject.classification
Otras Ciencias de la Salud
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Combination of defined catwalk gait parameters for predictive locomotion recovery in experimental spinal cord injury rat models
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-07-01T17:49:43Z
dc.identifier.eissn
2373-2822
dc.journal.volume
8
dc.journal.number
2
dc.journal.pagination
1-14
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Timotius, Ivanna K.. Friedrich-Alexander-Universität Erlangen-Nürnberg; Alemania. Universitas Kristen Satya Wacana; Indonesia
dc.description.fil
Fil: Bieler, Lara. Paracelsus Medizinische Privatuniversitat; Austria
dc.description.fil
Fil: Couillard Despres, Sebastien. Paracelsus Medizinische Privatuniversitat; Austria
dc.description.fil
Fil: Sandner, Beatrice. Universitätsklinikum Heidelberg; Alemania
dc.description.fil
Fil: Garcia Ovejero, Daniel. Gobierno de Castilla-La Mancha. Hospital Nacional de Parapléjicos; España
dc.description.fil
Fil: Labombarda, Maria Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
dc.description.fil
Fil: Estrada, Veronica. Heinrich-Heine-Universität Düsseldorf; Alemania
dc.description.fil
Fil: Müller, Hans W.. Heinrich-Heine-Universität Düsseldorf; Alemania
dc.description.fil
Fil: Winkler, Jürgen. Friedrich-Alexander-Universität Erlangen-Nürnberg; Alemania
dc.description.fil
Fil: Klucken, Jochen. Friedrich-Alexander-Universität Erlangen-Nürnberg; Alemania
dc.description.fil
Fil: Eskofier, Bjoern. Friedrich-Alexander-Universität Erlangen-Nürnberg; Alemania
dc.description.fil
Fil: Weidner, Norbert. Universitätsklinikum Heidelberg; Alemania
dc.description.fil
Fil: Puttagunta, Radhika. Universitätsklinikum Heidelberg; Alemania
dc.journal.title
eNeuro
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.eneuro.org/content/8/2/ENEURO.0497-20.2021.long
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1523/ENEURO.0497-20.2021
Archivos asociados