Artículo

The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds

Fernández, Daniel; Wenck, Mary Anne; Craig, Sydney P.; Delfino, Jose MariaIcon
Fecha de publicación: 09/2004
Editorial: Pergamon-Elsevier Science Ltd
Revista: Biorganic and Medicinal Chemistry Letters
ISSN: 0960-894X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

We identified and tested bisphosphonates as inhibitors of a protozoan molecular target. Computational modeling studies demonstrated that these compounds are mimics of the natural substrate of the enzyme. The most potent bisphosphonates in vitro are pamidronate and risedronate, which inhibit the purine transferase from Trypanosoma cruzi in the micromolar range.
Palabras clave: BISPHOSPHONATES , CHAGAS , HPRT INHIBITORS , TRYPANOSOMA CRUZI
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/137269
URL: https://www.sciencedirect.com/science/article/abs/pii/S0960894X04007978
DOI: http://dx.doi.org/10.1016/j.bmcl.2004.06.042
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Articulos(IQUIFIB)
Articulos de INST.DE QUIMICA Y FISICO-QUIMICA BIOLOGICAS "PROF. ALEJANDRO C. PALADINI"
Citación
Fernández, Daniel; Wenck, Mary Anne; Craig, Sydney P.; Delfino, Jose Maria; The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds; Pergamon-Elsevier Science Ltd; Biorganic and Medicinal Chemistry Letters; 14; 17; 9-2004; 4501-4504
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