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dc.contributor.author
Abruzzese, Giselle Adriana
dc.contributor.author
Motta, Alicia Beatriz
dc.date.available
2017-03-10T19:02:44Z
dc.date.issued
2015-08
dc.identifier.citation
Abruzzese, Giselle Adriana; Motta, Alicia Beatriz; Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary Syndrome; Bentham Science Publishers; Current Pharmaceutical Design.; 21; 35; 8-2015; 5144-5150
dc.identifier.issn
1381-6128
dc.identifier.uri
http://hdl.handle.net/11336/13723
dc.description.abstract
Nonalcoholic fatty liver disease (NAFLD) is defined as the accumulation of triglycerides (TGs) within hepatocytes exceeding 5 % of liver weight. NAFLD is a spectrum of pathological processes from nonalcoholic fatty liver or simple steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. As NAFLD induces metabolic syndrome (MS), then, NAFLD is associated with insulin resistance (IR), type 2 diabetes mellitus (T2DM), hypertension and even Polycystic Ovary Syndrome (PCOS). Because it is well established that patients carrying gene mutations also develop NAFLD in the absence of IR, the genetic predisposition to NAFLD is also discussed. Little is known about the diagnosis and treatment of NAFLD in children and adolescents and the lack of non-invasive diagnostic tools in these populations is a major problem faced by physicians. The present review aims to discuss recent findings of NAFLD in children and adolescents and, considering the features in common with PCOS, we also discuss their relationship.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Nonalcoholic Fatty Liver Disease
dc.subject
Polycystic Ovary Syndrome
dc.subject
Triglycerides
dc.subject
Adolescents
dc.subject
Children
dc.subject
Metabolic Syndrome
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Insulin Resistance
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Obesity
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Obstetricia y Ginecología
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Medicina Clínica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Nonalcoholic fatty liver disease in children and adolescents: relationship with Polycystic Ovary Syndrome
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-09T15:06:51Z
dc.identifier.eissn
1873-4286
dc.journal.volume
21
dc.journal.number
35
dc.journal.pagination
5144-5150
dc.journal.pais
Emiratos Árabes Unidos
dc.journal.ciudad
Sharjah
dc.description.fil
Fil: Abruzzese, Giselle Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Motta, Alicia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.journal.title
Current Pharmaceutical Design.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/135208/article
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/1381612821666150928105959


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