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dc.contributor.author
Kokjohn, Tyler A.  
dc.contributor.author
Van Vickle, Gregory D.  
dc.contributor.author
Maarouf, Chera L.  
dc.contributor.author
Kalback, Walter M.  
dc.contributor.author
Hunter, Jesse M.  
dc.contributor.author
Daugs, Ian D.  
dc.contributor.author
Luehrs, Dean C.  
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Lopez, John  
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Brune, Daniel  
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Sue, Lucia I.  
dc.contributor.author
Beach, Thomas G.  
dc.contributor.author
Castaño, Eduardo Miguel  
dc.contributor.author
Roher, Alex E.  
dc.date.available
2017-03-09T21:42:54Z  
dc.date.issued
2011  
dc.identifier.citation
Kokjohn, Tyler A.; Van Vickle, Gregory D.; Maarouf, Chera L.; Kalback, Walter M.; Hunter, Jesse M.; et al.; Chemical characterization of pro-inflammatory amyloid-beta peptides in human atherosclerotic lesions and platelets; Elsevier Science; Biochimica Et Biophysica Acta - Molecular Basis Of Disease; 1812; 11; -1-2011; 1508-1514  
dc.identifier.issn
0925-4439  
dc.identifier.uri
http://hdl.handle.net/11336/13722  
dc.description.abstract
Amyloid-β (Aβ) peptides are intimately involved in the inflammatory pathology of atherosclerotic vascular disease (AVD) and Alzheimer's disease (AD). Although substantial amounts of these peptides are produced in the periphery, their role and significance to vascular disease outside the brain requires further investigation. Amyloid-β peptides present in the walls of human aorta atherosclerotic lesions as well as activated and non-activated human platelets were isolated using sequential size-exclusion columns and HPLC reverse-phase methods. The Aβ peptide isolates were quantified by ELISA and structurally analyzed using MALDI-TOF mass spectrometry procedures. Our experiments revealed that both aorta and platelets contained Aβ peptides, predominately Aβ40. The source of the Aβ pool in aortic atherosclerosis lesions is probably the activated platelets and/or vascular wall cells expressing APP/PN2. Significant levels of Aβ42 are present in the plasma, suggesting that this reservoir makes a minor contribution to atherosclerotic plaques. Our data reveal that although aortic atherosclerosis and AD cerebrovascular amyloidosis exhibit clearly divergent end-stage manifestations, both vascular diseases share some key pathophysiological promoting elements and pathways. Whether they happen to be deposited in vessels of the central nervous system or atherosclerotic plaques in the periphery, Aβ peptides may promote and perhaps synergize chronic inflammatory processes which culminate in the degeneration, malfunction and ultimate destruction of arterial walls.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier Science  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Atherosclerosis  
dc.subject
Platelet  
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Amyloid-Beta  
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Vascular Inflammation  
dc.subject.classification
Medicina Química  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Chemical characterization of pro-inflammatory amyloid-beta peptides in human atherosclerotic lesions and platelets  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-02-07T13:52:00Z  
dc.journal.volume
1812  
dc.journal.number
11  
dc.journal.pagination
1508-1514  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Kokjohn, Tyler A.. Banner Sun Health Research Institute; Estados Unidos. Midwestern University; Estados Unidos  
dc.description.fil
Fil: Van Vickle, Gregory D.. Banner Sun Health Research Institute; Estados Unidos  
dc.description.fil
Fil: Maarouf, Chera L.. Banner Sun Health Research Institute; Estados Unidos  
dc.description.fil
Fil: Kalback, Walter M.. Banner Sun Health Research Institute; Estados Unidos  
dc.description.fil
Fil: Hunter, Jesse M.. Banner Sun Health Research Institute; Estados Unidos  
dc.description.fil
Fil: Daugs, Ian D.. Banner Sun Health Research Institute; Estados Unidos  
dc.description.fil
Fil: Luehrs, Dean C.. Banner Sun Health Research Institute; Estados Unidos  
dc.description.fil
Fil: Lopez, John. Arizona State University; Estados Unidos  
dc.description.fil
Fil: Brune, Daniel. Arizona State University; Estados Unidos  
dc.description.fil
Fil: Sue, Lucia I.. Banner Sun Health Research Institute; Estados Unidos  
dc.description.fil
Fil: Beach, Thomas G.. Banner Sun Health Research Institute; Estados Unidos  
dc.description.fil
Fil: Castaño, Eduardo Miguel. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Roher, Alex E.. Banner Sun Health Research Institute; Estados Unidos  
dc.journal.title
Biochimica Et Biophysica Acta - Molecular Basis Of Disease  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bbadis.2011.07.004  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0925443911001475