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dc.contributor.author
Villalobos, Rafael
dc.contributor.author
Domínguez, Armando
dc.contributor.author
Ganem, Adriana
dc.contributor.author
Vidales, Ana Maria
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dc.contributor.author
Cordero, Salomón
dc.date.available
2021-07-27T19:54:12Z
dc.date.issued
2009-12
dc.identifier.citation
Villalobos, Rafael; Domínguez, Armando; Ganem, Adriana; Vidales, Ana Maria; Cordero, Salomón; One-dimensional drug release from finite Menger sponges: In silico simulation; Pergamon-Elsevier Science Ltd; Chaos, Solitons And Fractals; 42; 5; 12-2009; 2875-2884
dc.identifier.issn
0960-0779
dc.identifier.uri
http://hdl.handle.net/11336/137127
dc.description.abstract
The purpose of this work was to evaluate the consequences of the spatial distribution of components in pharmaceutical matrices type Menger sponge on the drug release kinetic from this kind of platforms by means of Monte Carlo computer simulation. First, six kinds of Menger sponges (porous fractal structures) with the same fractal dimension, df = 2.727, but with different random walk dimension, dw ∈ [2.149, 3.183], were constructed as models of drug release device. Later, Monte Carlo simulation was used to describe drug release from these structures as a diffusion-controlled process. The obtained results show that drug release from Menger sponges is characterized by an anomalous behavior: there are important effects of the microstructure anisotropy, and porous structures with the same fractal dimension but with different topology produce different release profiles. Moreover, the drug release kinetic from heteromorphic structures depends on the axis used to transport the material to the external medium. Finally, it was shown that the number of releasing sites on the matrix surface has a significant impact on drug release behavior and it can be described quantitatively by the Weibull function.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Pergamon-Elsevier Science Ltd
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Menger sponge
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Diffusion-controlled process
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Drug release
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Weibull function
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Monte Carlo simulation
dc.subject.classification
Otras Ciencias Físicas
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dc.subject.classification
Ciencias Físicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
One-dimensional drug release from finite Menger sponges: In silico simulation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-28T20:46:34Z
dc.journal.volume
42
dc.journal.number
5
dc.journal.pagination
2875-2884
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Villalobos, Rafael. Universidad Nacional Autónoma de México; México
dc.description.fil
Fil: Domínguez, Armando. Universidad Autónoma Metropolitana; México
dc.description.fil
Fil: Ganem, Adriana. Universidad Nacional Autónoma de México; México
dc.description.fil
Fil: Vidales, Ana Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich". Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto de Física Aplicada "Dr. Jorge Andrés Zgrablich"; Argentina
dc.description.fil
Fil: Cordero, Salomón. Universidad Autónoma Metropolitana; México
dc.journal.title
Chaos, Solitons And Fractals
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0960077909003671
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.chaos.2009.04.007
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