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Artículo

Evaluating ternary systems with oligosaccharides as a strategy to improve the biopharmaceutical properties of furosemide

Abraham Miranda, JulietaIcon ; Garnero, ClaudiaIcon ; Zoppi, ArianaIcon ; Chattah, Ana KarinaIcon ; Sterren, Vanesa BeatrizIcon ; Santiago de Oliveira, Yara; Ayala, Alejandro P.; Longhi, Marcela RaquelIcon
Fecha de publicación: 06/2020
Editorial: Elsevier Science
Revista: Materials Science and Engineering: C
ISSN: 0928-4931
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
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Resumen

Novel ternary systems with β-cyclodextrin or maltodextrin and triethanolamine as the third component were developed with the aim of improving the oral bioavailability of furosemide. These new solids were characterized by solid-state nuclear magnetic resonance, Fourier transform infrared and Raman spectroscopy, X-ray powder diffractometry, scanning electron microscopy, thermogravimetric analysis, and differential scanning calorimetry. The solubility, dissolution and stability (chemical and physical) were studied. Among the most important results, it was observed that both ternary systems showed an important enhancement in the solubility of the drug. In particular, the system obtained by combination of β-cyclodextrin and TEA exhibited improvement in the dissolution profiles and photo-stability of furosemide compared with the binary system previously reported. Moreover, this system constitutes an interesting therapeutic alternative as it did not produce cellular toxicity compared with free furosemide. In conclusion, the results obtained revealed that this ternary system establishes a promising approach for oral delivery of the drug.
Palabras clave: CELLULAR TOXICITY , DISSOLUTION , FUROSEMIDE , OLIGOSACCHARIDES , STABILITY , TRIETHANOLAMINE
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/137096
DOI: http://dx.doi.org/10.1016/j.msec.2020.110793
URL: https://www.sciencedirect.com/science/article/abs/pii/S0928493119333090
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Articulos(IFEG)
Articulos de INST.DE FISICA ENRIQUE GAVIOLA
Citación
Abraham Miranda, Julieta; Garnero, Claudia; Zoppi, Ariana; Chattah, Ana Karina; Sterren, Vanesa Beatriz; et al.; Evaluating ternary systems with oligosaccharides as a strategy to improve the biopharmaceutical properties of furosemide; Elsevier Science; Materials Science and Engineering: C; 111; 6-2020; 1-33
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