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dc.contributor.author
Fernández Fierro, Ayleen
dc.contributor.author
Funes, Samanta Celeste
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dc.contributor.author
Rios, Mariana
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Covián, Camila
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González, Jorge
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Kalergis, Alexis M.
dc.date.available
2021-07-27T14:29:05Z
dc.date.issued
2021-01
dc.identifier.citation
Fernández Fierro, Ayleen; Funes, Samanta Celeste; Rios, Mariana; Covián, Camila; González, Jorge; et al.; Immune modulation by inhibitors of the HO system; MDPI AG; International Journal of Molecular Sciences; 22; 1; 1-2021; 1-18; 294
dc.identifier.issn
1661-6596
dc.identifier.uri
http://hdl.handle.net/11336/137035
dc.description.abstract
The heme oxygenase (HO) system involves three isoforms of this enzyme, HO-1, HO-2, and HO-3. The three of them display the same catalytic activity, oxidating the heme group to produce biliverdin, ferrous iron, and carbon monoxide (CO). HO-1 is the isoform most widely studied in proinflammatory diseases because treatments that overexpress this enzyme promote the generation of anti-inflammatory products. However, neonatal jaundice (hyperbilirubinemia) derived from HO overexpression led to the development of inhibitors, such as those based on metaloproto-and meso-porphyrins inhibitors with competitive activity. Further, non-competitive inhibitors have also been identified, such as synthetic and natural imidazole-dioxolane-based, small synthetic molecules, inhibitors of the enzyme regulation pathway, and genetic engineering using iRNA or CRISPR cas9. Despite most of the applications of the HO inhibitors being related to metabolic diseases, the beneficial effects of these molecules in immune-mediated diseases have also emerged. Different medical implications, including cancer, Alzheimer´s disease, and infections, are discussed in this article and as to how the selective inhibition of HO isoforms may contribute to the treatment of these ailments.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
MDPI AG
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HEME OXYGENASE-1
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HEME OXYGENASE-2
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INHIBITORS
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IMMUNOMODULATION
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INFECTIONS
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CANCER
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Immune modulation by inhibitors of the HO system
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2021-04-28T20:36:42Z
dc.identifier.eissn
1422-0067
dc.journal.volume
22
dc.journal.number
1
dc.journal.pagination
1-18; 294
dc.journal.pais
Suiza
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dc.description.fil
Fil: Fernández Fierro, Ayleen. Pontificia Universidad Católica de Chile; Chile
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Fil: Funes, Samanta Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; Argentina
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Fil: Rios, Mariana. Pontificia Universidad Católica de Chile; Chile
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Fil: Covián, Camila. Pontificia Universidad Católica de Chile; Chile
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Fil: González, Jorge. Pontificia Universidad Católica de Chile; Chile
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Fil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; Chile
dc.journal.title
International Journal of Molecular Sciences
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1422-0067/22/1/294
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/ijms22010294
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