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dc.contributor.author
Peralta, Mariana Andrea
dc.contributor.author
Santi, María Daniela
dc.contributor.author
Agnese, Alicia Mariel
dc.contributor.author
Cabrera, Jose Luis
dc.contributor.author
Ortega, María Gabriela
dc.date.available
2017-03-09T20:11:51Z
dc.date.issued
2014-12
dc.identifier.citation
Peralta, Mariana Andrea; Santi, María Daniela; Agnese, Alicia Mariel; Cabrera, Jose Luis; Ortega, María Gabriela; Flavanoids from Dalea elegans: chemical reassignment and determination of kinetics parameters related to their anti-tyrosinase activity; Elsevier Science; Phytochemistry Letters; 10; 12-2014; 260-267
dc.identifier.issn
1874-3900
dc.identifier.uri
http://hdl.handle.net/11336/13699
dc.description.abstract
In the first chemical investigation developed on the species Dalea elegans twenty years ago, the occurrence of two prenylated derivatives of pinocembrin was reported: 2′,4′-dihydroxy-5′-(1‴,1‴-dimethylallyl)-6-prenylpinocembrin (6PP) given as a new structure in this family of compounds, and another derivative of already known structure, 6-prenylpinocembrin (6P). In the present paper, their structures were again analyzed by using spectroscopic techniques, especially 2D NMR. Based on the evidence obtained it is proposed the reassignment of both flavanones as: 2′,4′-dihydroxy-5′-(1‴,1‴-dimethylallyl)-8-prenylpinocembrin (8PP) for the first and 8-prenylpinocembrin (8P) for the last. Additionally, triangularin, demethoxymatteucinol, comptonin and 7-hydroxy-5-methoxy-6,8-dimethylflavanone were isolated from aerial parts of D. elegans and informed by the first time for this species. All of these compounds were evaluated in vitro in relation to the antityrosinase effect by using a spectrophotometric method. Compound 8PP (IC50 2.32 ± 0.01 μM) exhibited the most potency and was two times more active than Kojic acid (IC50 4.93 ± 0.01 μM) used as a positive control. Triangularin also has shown an important inhibitory activity. Kinetic studies were performed for both compounds. Hence, new tyrosinase inhibitors with potential applications in pharmacy and cosmetic industry are presented.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Dalea Elegans
dc.subject
Fabaceae
dc.subject
Prenylated Flavonone
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C-Methyl Flavonoids
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Chemical Reassignment
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Antityrosinase Activity
dc.subject.classification
Otras Ciencias Naturales y Exactas
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Otras Ciencias Naturales y Exactas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Flavanoids from Dalea elegans: chemical reassignment and determination of kinetics parameters related to their anti-tyrosinase activity
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-01T18:04:28Z
dc.identifier.eissn
1876-7486
dc.journal.volume
10
dc.journal.pagination
260-267
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Peralta, Mariana Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
dc.description.fil
Fil: Santi, María Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
dc.description.fil
Fil: Agnese, Alicia Mariel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
dc.description.fil
Fil: Cabrera, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
dc.description.fil
Fil: Ortega, María Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina. Universidad Nacional de Cordoba. Facultad de Ciencias Quimicas. Departamento de Farmacia; Argentina
dc.journal.title
Phytochemistry Letters
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.phytol.2014.10.012
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1874390014001888
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