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dc.contributor.author
Odeon, Maria Mercedes
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dc.contributor.author
Salatino, Adrián Emanuel
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dc.contributor.author
Acosta, Gabriela Beatriz
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dc.date.available
2017-03-09T19:53:30Z
dc.date.issued
2013-03
dc.identifier.citation
Odeon, Maria Mercedes; Salatino, Adrián Emanuel; Acosta, Gabriela Beatriz; Consequences of postnatal stress: maternal separation in rats induces long-lasting changes on glutamate transporters; OMICS International; Journal of Clinical & Experimental Pharmacology; 3; 121; 3-2013; 1-7
dc.identifier.issn
2161-1459
dc.identifier.uri
http://hdl.handle.net/11336/13691
dc.description.abstract
Background: There is increasing evidence that environmental factors, particularly stressful events experienced early in life, increase the risk of developing a psychiatric illness and/or a behavioural disorder. The aim of this study was to evaluate the effects of acute and chronic maternal separation (AMS and CMS) plus cold stress on the expression patterns of Glutamate Transporters (TGlus) in the developing and young adult Central Nervous System (CNS). As regulation of Glutamate (Glu) extracellular levels is of key importance, sodium-dependent Glu uptake using synaptosome-enriched fractions isolated from Frontal Cortex (FC) and Hippocampus (Hic) was also studied. Results: In animals under AMS stress found that Glu uptake decreases with respect to control groups. Meanwhile in CMS did not observe changes on Glu uptake in adult animals. These data would suggest the existence of an adaptive mechanism that could compensate the effect of AMS and CMS plus cold stress on glutamate uptake. Western blotting was performed in homogenates prepared from FC and Hic from both neonate and young adult rat brains. These blots exposed that homogenates include GLT-1 and EAAC-1 proteins and their levels varied in different areas of the rat brain and with the age of animals. Conclusions: During early postnatal life, exposure to various stressors lead to the development of various neurological, psychiatric, neurodegenerative and behavioral disorders, expressible in adult life in the case of chronic stress. These results demonstrate that adverse early life events have profound and persistent effects on brain function and may represent a risk factor for the development of psychopathology later life.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
OMICS International
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/
dc.subject
Acute
dc.subject
Chronc
dc.subject
Maternal Separation
dc.subject
Cold Stress
dc.subject
Glutamate Transporters
dc.subject
Uptake
dc.subject
Western Blot
dc.subject.classification
Otras Ciencias de la Salud
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dc.subject.classification
Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Consequences of postnatal stress: maternal separation in rats induces long-lasting changes on glutamate transporters
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-03-06T18:05:58Z
dc.journal.volume
3
dc.journal.number
121
dc.journal.pagination
1-7
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Los Ángeles
dc.description.fil
Fil: Odeon, Maria Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
dc.description.fil
Fil: Salatino, Adrián Emanuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina
dc.description.fil
Fil: Acosta, Gabriela Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas (i); Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas. Cátedra de Fisiopatología; Argentina
dc.journal.title
Journal of Clinical & Experimental Pharmacology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/consequences-of-postnatal-stress-maternal-separation-in-rats-induces-long-lasting-changes-on-glutamate-transporters-2161-1459.1000121.php?aid=12098
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4172/2161-1459.1000121
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