Artículo
The effect of D-aspartate on luteinizing hormone-releasing hormone, α-melanocyte-stimulating hormone, GABA and dopamine release
Pampillo, Macarena; Scimonelli, Teresa; Bottino, Maria Cecilia
; Duvilanski, Beatriz Haydee
; Rettori, Valeria; Seilicovich, Adriana
; Lasaga, Mercedes Isabel
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Fecha de publicación:
12/2002
Editorial:
Lippincott Williams
Revista:
Neuroreport
ISSN:
0959-4965
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Since D-aspartate stimulates prolactin and LH release, our objective was to determine whether D-aspartate modifies the release of hypothalamic and posterior pituitary factors involved in the control of their secretion and whether its effects on these tissues are exerted through NMDA receptors and mediated by nitric oxide. In the hypothalamus, D-aspartate stimulated luteinizing hormone-releasing hormone (LHRH), alpha-melanocyte-stimulating hormone (alpha-MSH) and GABA release and inhibited dopamine release through interaction with NMDA receptors. It increased nitric oxide synthase (NOS) activity, and its effects on LHRH and hypothalamic GABA release were blunted when NOS was inhibited. In the posterior pituitary gland, D-aspartate inhibited GABA release but had no effect on dopamine or alpha-MSH release. We report that D-aspartate differentially affects the release of hypothalamic and posterior pituitary factors involved in the regulation of pituitary hormone secretion.
Palabras clave:
D-aspartate
,
LHRH
,
alpha-MSH
,
GABA
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(INBIOMED)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Citación
Pampillo, Macarena; Scimonelli, Teresa; Bottino, Maria Cecilia; Duvilanski, Beatriz Haydee; Rettori, Valeria; et al.; The effect of D-aspartate on luteinizing hormone-releasing hormone, α-melanocyte-stimulating hormone, GABA and dopamine release; Lippincott Williams; Neuroreport; 13; 12-2002; 2341-2344
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