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Artículo

Design of novel oral ricobendazole formulation applying melting solidification printing process (MESO-PP): An innovative solvent-free alternative method for 3D printing using a simplified concept and low temperature

Real, Juan PabloIcon ; Barberis, Maria EugeniaIcon ; Camacho, Nahuel MatiasIcon ; Sanchez Bruni, Sergio FabianIcon ; Palma, Santiago DanielIcon
Fecha de publicación: 25/09/2020
Editorial: Elsevier Science
Revista: International Journal Of Pharmaceutics
ISSN: 0378-5173
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
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Resumen

This paper describes a melting solidification printing process (MESO-PP) capable of obtaining printed oral solid dosage forms in a safe, versatile, and robust manner avoiding the use of solvents and high temperatures. MESO-PP and Gelucire® 50/13 (fatty polyethylene glycol esters) as ink can be used to obtain a floating sustained-release system with the aim of improving the dissolution and absorption of drugs, such as ricobendazole (RBZ), which have a low and erratic bioavailability. Gelucire 50/13 can be considered a good material to formulate inks using MESO-PP. As a model, the RBZ allowed us to assess that there were no changes in crystallinity and the API-ink interactions were ruled out using TGA, DSC, XRD and FT-IR assays. A batch of printlets, obtained using MESO-PP, fulfilled USP requirements regarding uniformity of mass (827 ± 9 mg) and drug content (211 ± 5 mg). Hardness and friability were 39.23 ± 9.65 N and 1.07 ± 0.5% respectively, just above the 1% USP tablet-friability limit. It was possible to obtain tablets of different sizes with high precision (r2 = 0.995). In vitro dissolution test showed that the printlet had a sustained-release of RBZ (only 7% after 15 min), that erosion was the predominant mechanism for drug release (n-value of Korsmeyer-Peppas equation = 0.991; r2 = 0.99) and that changes in the internal structures modify the release. Consequently, MESO-PP can be considered an excellent alternative to obtain solid pharmaceutical dosage forms with variable geometries for different pharmaceutical applications.
Palabras clave: 3D PRINTING , ALBENDAZOLE SULFOXIDE , GASTRO-FLOATING , GELUCIRE 50/13 , SUSTAINED RELEASE
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/136837
URL: https://www.sciencedirect.com/science/article/pii/S0378517320306372
DOI: https://doi.org/10.1016/j.ijpharm.2020.119653
Colecciones
Articulos(UNITEFA)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Citación
Real, Juan Pablo; Barberis, Maria Eugenia; Camacho, Nahuel Matias; Sanchez Bruni, Sergio Fabian; Palma, Santiago Daniel; Design of novel oral ricobendazole formulation applying melting solidification printing process (MESO-PP): An innovative solvent-free alternative method for 3D printing using a simplified concept and low temperature; Elsevier Science; International Journal Of Pharmaceutics; 587; 25-9-2020; 1-13
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